Duncan W, Quilty P M
Radiother Oncol. 1986 Dec;7(4):299-310. doi: 10.1016/s0167-8140(86)80059-7.
The results are reported of a large series of patients with transitional cell cancer of the bladder, treated in Edinburgh between 1971 and 1982. Analysis of pre-treatment characteristics for patients with transitional cell bladder cancer showed that tumour category was significantly associated with grade and tumour size. Complete local tumour regression at follow-up cystoscopy was achieved in 45.9% of patients who completed radical megavoltage X-ray therapy. Patients with grade 2 or 3 cancer, a solid cancer or a tumour of less than 8 cm in size had significantly improved complete regression rates. Lasting local tumour control after initial complete regression was better in patients with grade 3 cancer. Complete regression was associated with improved survival for all but patients with T1 cancer. The poorest (uncorrected) survival rates were seen in patients over 79 years of age, those with T4 cancer, an ulcerated cancer, a grade 3 cancer or a tumour of more than 7 cm in size. Metastases were more often seen in patients with grade 3 or T3/T4 cancer. Severe late radiation-related complications were seen in 14.8% of patients.
报告了1971年至1982年在爱丁堡接受治疗的一大系列膀胱移行细胞癌患者的结果。对膀胱移行细胞癌患者的治疗前特征分析表明，肿瘤类别与分级和肿瘤大小显著相关。在完成根治性兆伏级X线治疗的患者中，45.9%在随访膀胱镜检查时实现了局部肿瘤完全消退。2级或3级癌症、实体癌或大小小于8 cm的肿瘤患者的完全消退率显著提高。3级癌症患者在初始完全消退后实现持久局部肿瘤控制的情况更好。除T1期癌症患者外，完全消退与生存率提高相关。79岁以上患者、T4期癌症患者、溃疡型癌症患者、3级癌症患者或大小超过7 cm的肿瘤患者的（未经校正的）生存率最差。3级或T3/T4期癌症患者更常出现转移。14.8%的患者出现严重的晚期放射相关并发症。
