Glebezdina N S, Olina A A, Nekrasova I V, Kuklina E M
Institute of Ecology and Genetics of Microorganisms, Russian Academy of Science, Ural Branch, 614081, Perm, Russia.
Ott Research Institute of Obstetrics, Gynecology, and Reproductology, 199034, St. Petersburg, Russia.
Dokl Biochem Biophys. 2019 May;484(1):13-16. doi: 10.1134/S1607672919010058. Epub 2019 Apr 22.
We investigated the role of epiphyseal hormone melatonin in the differentiation of naive CD4 T cells into regulatory T cells (Treg). The hormone at physiological and pharmacological concentrations inhibited Treg differentiation, decreasing both the proportion of CD4FOXP3 cells in the culture and the level of TGF-β, the key cytokine for this T cell subpopulation. The inhibitory effect of exogenous melatonin was due to its interaction with the membrane receptors MT1 and MT2. At the same time, the signals realized through RORα-the nuclear receptor for melatonin-stimulated Treg formation; however, they were considerably weaker than the signals from the membrane receptors and were overlapped by the latter. Since the Treg subpopulation plays an important role in physiological and pathological processes in the body, the revealed effects of melatonin should be taken into account in its therapeutic use.
我们研究了骨骺激素褪黑素在初始CD4 T细胞分化为调节性T细胞（Treg）过程中的作用。生理和药理浓度的该激素均抑制Treg分化，降低培养物中CD4FOXP3细胞的比例以及该T细胞亚群的关键细胞因子TGF-β的水平。外源性褪黑素的抑制作用归因于其与膜受体MT1和MT2的相互作用。同时，通过褪黑素的核受体RORα实现的信号刺激Treg形成；然而，它们比来自膜受体的信号弱得多，并被后者所掩盖。由于Treg亚群在机体的生理和病理过程中起重要作用，因此在褪黑素的治疗应用中应考虑到其已揭示的作用。
