内源性褪黑素在孕期Th17/Treg平衡调节中的作用
Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy.
作者信息
Glebezdina N S, Olina A A, Nekrasova I V, Kuklina E M
机构信息
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
E. A. Wagner Perm State Medical University, Perm, Russia.
出版信息
Bull Exp Biol Med. 2018 Mar;164(4):462-465. doi: 10.1007/s10517-018-4013-1. Epub 2018 Mar 5.
We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4RORγt and CD4FoxP3T cells and their key products IL-17A and TGF-β was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.
我们研究了内源性褪黑素在孕期产生白细胞介素-17的T细胞（Th17）和调节性T细胞（Treg）的发育及功能中的作用。该研究在体外和体内进行，以内源褪黑素依赖信号阻断条件下的自身血清作为内源性褪黑素的来源。证实了该激素参与CD4RORγt和CD4FoxP3T细胞及其关键产物白细胞介素-17A和转化生长因子-β的分化调节。已知正常妊娠过程会因激素变化而导致Th17/Treg比值降低。孕期所研究亚群对褪黑素的敏感性可能会影响妊娠结局。
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