从鸟肠球菌制备重组抗菌肽阿维菌素A的生物技术方法及表征
Biotechnological Method of Preparation and Characterization of Recombinant Antimicrobial Peptide Avicin A from Enterococcus avium.
作者信息
Balandin S V, Finkina E I, Nurmukhamedova E K-A, Tagaev A A, Umnyakova E S, Kokryakov V N, Shvets V I, Ovchinnikova T V
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Institute of Experimental Medicine, Almazov National Medical Research Center, 197341, St. Petersburg, Russia.
出版信息
Dokl Biochem Biophys. 2019 May;484(1):42-44. doi: 10.1134/S1607672919010113. Epub 2019 Apr 22.
Avicin A is a bacteriocin from the gram-positive bacterium Enterococcus avium. It exhibits a high microbicidal activity against bacteria of the genus Listeria, a causative agent of the severe human infection listeriosis. We developed a biotechnological method for obtaining avicin A and characterized its structure and biological activity. We also proposed a possible mechanism of the antimicrobial action of avicin A.
阿维菌素A是一种来自革兰氏阳性鸟肠球菌的细菌素。它对李斯特菌属细菌具有很高的杀菌活性，李斯特菌属是严重人类感染李斯特菌病的病原体。我们开发了一种获取阿维菌素A的生物技术方法，并对其结构和生物活性进行了表征。我们还提出了阿维菌素A抗菌作用的可能机制。
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