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在东非索马里人群中存在一种产生罕见Cx(Rh9)抗原的“新”Rh基因复合体的证据。

Evidence for a 'new' Rh gene complex producing the rare Cx (Rh9) antigen in the Somali population of East Africa.

作者信息

Sistonen P, Abdulle O A, Sahid M

出版信息

Transfusion. 1987 Jan-Feb;27(1):66-8. doi: 10.1046/j.1537-2995.1987.27187121479.x.

Abstract

Four unrelated propositi with an unusual Cx-positive Rh phenotype were found during a population survey of 513 Somalis. The Rh phenotypes of the propositi and their available relatives showed that the gene that produces the Cx antigen differs from that found in whites in that it is inherited with an Rh gene complex that produces no C or D. Instead, this gene complex produced es, c, and probably V, although it appeared that no f (ce) antigen was made. These findings suggest that Cx cannot be considered a simple variant form of C but rather a distinct rare Rh antigen that may occur in association with different Rh gene complexes.

摘要

在对513名索马里人的群体调查中,发现了4名无亲缘关系的具有异常Cx阳性Rh表型的先证者。这些先证者及其可获取的亲属的Rh表型表明,产生Cx抗原的基因与白人中发现的基因不同,它与一个不产生C或D的Rh基因复合体一起遗传。相反,这个基因复合体产生了es、c,可能还有V,尽管似乎没有产生f(ce)抗原。这些发现表明,Cx不能被视为C的简单变异形式,而是一种独特的罕见Rh抗原,可能与不同的Rh基因复合体相关联。

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