Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Neurology, Mediplex Sejong Hospital, Incheon, Korea.
PLoS One. 2019 Apr 23;14(4):e0215750. doi: 10.1371/journal.pone.0215750. eCollection 2019.
Essential tremor (ET) is a common movement disorder characterized by postural or kinetic tremor. We aimed to evaluate median nerve enlargement in patients with ET using ultrasonography (USG). Thirty-eight hands from 19 patients with ET and 24 hands from 13 controls underwent nerve conduction studies (NCS) and USG at the wrist. Tremor severity was measured using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS). The median nerve cross sectional area (mCSA) in USG and NCS parameters were compared using ANCOVA. We evaluated the correlation between mCSA and NCS parameters or FTM-TRS scores using linear regression analysis. mCSA was significantly larger (p<0.001) and NCS parameters were different in two groups. Also, mCSA was negatively correlated with part B and C scores of FTM-TRS (p<0.001 and p = 0.039, respectively). In conclusion, median nerve enlargement with the changes of NCS parameters was observed and correlated with the severity of tremor in patients with ET.
特发性震颤（ET）是一种常见的运动障碍，其特征为姿势性或运动性震颤。我们旨在使用超声检查（USG）评估 ET 患者正中神经的增大。19 名 ET 患者的 38 只手和 13 名对照者的 24 只手接受了腕部神经传导研究（NCS）和 USG。震颤严重程度使用 Fahn-Tolosa-Marin 震颤评定量表（FTM-TRS）进行测量。使用协方差分析比较 USG 和 NCS 参数中的正中神经横截面积（mCSA）。我们使用线性回归分析评估 mCSA 与 NCS 参数或 FTM-TRS 评分之间的相关性。mCSA 明显增大（p<0.001），两组的 NCS 参数不同。此外，mCSA 与 FTM-TRS 的 B 部分和 C 部分评分呈负相关（p<0.001 和 p = 0.039）。总之，在 ET 患者中观察到正中神经增大伴有 NCS 参数的变化，并与震颤的严重程度相关。
