Red Cross Hospital, Athens, Greece.
2nd Department of Ophthalmology, University of Athens, Athens, Greece.
Ophthalmic Res. 2020;63(1):13-17. doi: 10.1159/000499370. Epub 2019 Apr 23.
The purpose of this retrospective study was to evaluate the disorganization of the retinal inner layers (DRIL) as a potential predictive factor of postoperative visual outcome in patients with idiopathic epiretinal membrane (iERM), treated with pars plana vitrectomy (PPV).
Participants in the study were 46 consecutive patients diagnosed with iERM, who underwent PPV. Best corrected visual acuity (BCVA) measurement and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline (preoperatively), and at months 3 and 6 postoperatively. DRIL and additional OCT parameters were assessed at 1-mm-wide foveal centered area.
DRIL was observed in 47.8% of patients at baseline. There was statistically significant improvement in BCVA and central retinal thickness (CRT) between baseline and months 6 and 12 in all patients. There was a statistically significant difference in BCVA and CRT change between patients with and without DRIL at months 6 and 12 compared to baseline, showing that there was a correlation between change in BCVA or CRT and baseline DRIL. Ellipsoid zone and external limiting membrane were intact in 91.3 and 95.7%, respectively, not affecting our results.
Baseline DRIL has been shown to be predictive of postoperative visual outcome in patients with iERM, treated with PPV.
本回顾性研究旨在评估特发性视网膜内皮层紊乱（DRIL）作为接受玻璃体切除术（PPV）治疗的特发性视网膜前膜（iERM）患者术后视力结果的潜在预测因子。
研究对象为 46 例经诊断为 iERM 并接受 PPV 治疗的连续患者。在基线（术前）、术后 3 个月和 6 个月进行最佳矫正视力（BCVA）测量和频域光相干断层扫描（SD-OCT）。在 1mm 宽的中心凹区域评估 DRIL 和其他 OCT 参数。
基线时 47.8%的患者观察到 DRIL。所有患者的 BCVA 和中心视网膜厚度（CRT）在基线至 6 个月和 12 个月之间均有统计学显著改善。与基线相比，6 个月和 12 个月时 DRIL 患者的 BCVA 和 CRT 变化之间存在统计学差异，表明 BCVA 或 CRT 的变化与基线 DRIL 之间存在相关性。椭圆体带和外部限制膜的完整性分别为 91.3%和 95.7%，这并不影响我们的结果。
基线 DRIL 已被证明可预测接受 PPV 治疗的 iERM 患者的术后视力结果。
