Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea.
Bio-Med Division, KIST-School UST, Seoul 02792, Korea.
Int J Mol Sci. 2019 Apr 22;20(8):1959. doi: 10.3390/ijms20081959.
Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients' brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy.
tau 病是一组与 tau 蛋白病理性修饰相关的神经退行性疾病的统称。tau 修饰受许多因素介导。最近，活性氧（ROS）因其对 tau 病的上下游作用而受到关注。在生理条件下，健康细胞会产生适度水平的 ROS 来自我防御外来入侵者。ROS 与抗氧化途径之间的失衡会导致过多 ROS 的积累。有明确的证据表明 ROS 直接促进 tau 病中的 tau 修饰。ROS 在 tau 病患者的大脑中也高度上调，抗氧化剂目前被开为 tau 病的潜在治疗剂。因此，氧化应激（OS）和 tau 病之间存在明确的联系，需要更详细地研究。在这篇综述中，我们将描述 ROS 的化学性质及其在 tau 病中的作用。
