龟裂杀菌素对多种革兰氏阳性菌菌株的抗菌活性。
Antibacterial activity of primycin against multiple strains of gram-positive bacteria.
作者信息
Uri J V
出版信息
Acta Microbiol Hung. 1986;33(2):141-6.
Crystalline primycin was found to be very active in broth dilution assay against Staphylococcus aureus (50 strains), Staphylococcus epidermidis (77 strains), Streptococcus faecalis (76 strains) and one strain of Listeria monocytogenes with minimal inhibitory concentrations (MIC) of 0.12-0.5 microgram/ml. The activity was influenced by the pH of the liquid medium with greater activity (lower MICs) at pH 8 against the majority of strains, than at pH 6 or 7.3. In disc agar diffusion assay Bacillus subtilis ATCC 6633 proved more sensitive than staphylococcus strains.
在肉汤稀释试验中发现，结晶原始霉素对金黄色葡萄球菌（50株）、表皮葡萄球菌（77株）、粪肠球菌（76株）和一株单核细胞增生李斯特菌具有很强的活性，其最低抑菌浓度（MIC）为0.12 - 0.5微克/毫升。液体培养基的pH值会影响其活性，在pH 8时，对大多数菌株的活性更高（MIC更低），高于pH 6或7.3时。在纸片琼脂扩散试验中，枯草芽孢杆菌ATCC 6633比葡萄球菌菌株更敏感。
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