阿根廷绵羊因弓形虫感染导致流产和死产的首例病例报告。
First case report of Toxoplasma gondii-induced abortions and stillbirths in sheep in Argentina.
作者信息
Gual I, Giannitti F, Hecker Y P, Shivers J, Entrocassi A C, Morrell E L, Pardini L, Fiorentino M A, Rodríguez Fermepin M, Unzaga J M, Cantón G J, Venturini M C, Moore D P
机构信息
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Av. Rivadavia 1917, CABA, Argentina.
Veterinary Population Medicine Department, College of Veterinary Medicine, University of Minnesota. 1333 Gortner Avenue, Saint Paul, MN, USA; Instituto Nacional de Investigación Agropecuaria (INIA), La Estanzuela. Ruta 50 Km. 11, Colonia, Uruguay.
出版信息
Vet Parasitol Reg Stud Reports. 2018 May;12:39-42. doi: 10.1016/j.vprsr.2018.01.001. Epub 2018 Jan 11.
The aim of this study is to report an episode of reproductive losses due to toxoplasmosis in a sheep flock in Argentina. A total of 15 abortions and 9 stillbirths were recorded in a flock of 190 Texel ewes. The affected ewes were more likely to be seropositive for Toxoplasma gondii (15/24) than ewes that delivered normal lambs (5/34, OR=9.6, 95%CI=2.7-34.0, p=0.0004). A pair of aborted twins was recovered for diagnostic investigation. One of these fetuses and its dam were seropositive for T. gondii. Histological examination of the two fetuses revealed non-suppurative myocarditis and epicarditis, portal hepatitis and multifocal necrotizing encephalitis with protozoal cysts in the brain. T. gondii was detected intralesionally by immunohistochemistry in one fetus and by PCR in both. Further investigations are necessary to evaluate the economic losses due to T. gondii in the Argentinean ovine industry.
本研究旨在报告阿根廷一群绵羊因弓形虫病导致的生殖损失事件。在一群190只特克塞尔母羊中，共记录到15例流产和9例死产。与产下正常羔羊的母羊相比，受影响的母羊更易出现弓形虫血清阳性（15/24）（产下正常羔羊的母羊为5/34，比值比=9.6，95%置信区间=2.7-34.0，p=0.0004）。回收了一对流产的双胞胎用于诊断调查。其中一只胎儿及其母羊弓形虫血清呈阳性。对这两只胎儿进行组织学检查发现，存在非化脓性心肌炎和心外膜炎、门静脉性肝炎以及多灶性坏死性脑炎，脑部有原生动物囊肿。通过免疫组化在一只胎儿的病变部位检测到了弓形虫，两只胎儿均通过聚合酶链反应检测到了弓形虫。有必要进一步调查以评估弓形虫给阿根廷养羊业造成的经济损失。
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