Chien Rory Chia-Ching, Telford Corbin R, Roy Shantanu, Ali Ibne Karim M, Shieh Wun-Ju, Confer Anthony W
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 250 McElroy Hall, Stillwater, OK 74078, USA.
Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 2065 W. Farm Road, Stillwater, OK 74078, USA.
Vet Parasitol Reg Stud Reports. 2018 Aug;13:156-159. doi: 10.1016/j.vprsr.2018.06.003. Epub 2018 Jun 12.
A 1-year-old Siberian Husky dog with acute-onset of seizures, recumbency, paddling, and muscular fasciculations was autopsied. A locally extensive hemorrhagic and malacic focus was noted in the right cerebral frontal cortex, and severe necrotizing and hemorrhagic, neutrophilic meningoencephalitis was diagnosed microscopically. Amoebic trophozoites and cysts were identified within the affected cerebral parenchyma and confirmed by indirect immunofluorescence assay and real-time PCR as Balamuthia mandrillaris. B. mandrillaris is found in soil and water and the infection has been reported in both immunocompromised and immunocompetent humans and rarely in the dog.
对一只1岁大的患有急性癫痫发作、卧地不起、划水动作和肌肉震颤的西伯利亚哈士奇犬进行了尸检。在右侧大脑额叶皮质发现了一个局部广泛的出血性和软化灶，显微镜检查诊断为严重的坏死性、出血性嗜中性脑膜脑炎。在受影响的脑实质内发现了阿米巴滋养体和包囊，并通过间接免疫荧光试验和实时聚合酶链反应确认为曼氏巴贝斯虫。曼氏巴贝斯虫存在于土壤和水中，免疫功能低下和免疫功能正常的人均有感染报告，在犬中则很少见。
