Limberg M B, McCaa C, Kissling G E, Kaufman H E
Am J Ophthalmol. 1987 Feb 15;103(2):194-7. doi: 10.1016/s0002-9394(14)74226-6.
Twenty patients with keratoconjunctivitis sicca used three different viscoelastic tear formulations and a polyvinyl alcohol artificial tear for two weeks each. Each formulation was used once every two waking hours in a controlled double-masked study. Eighteen patients reported marked improvement over the course of the study, in terms of the severity of itching, burning, and foreign body sensation. Corneal staining and mucous strand formation were also reduced in patients with these manifestations. No formulation was preferred by a majority of patients or proved superior in treating signs of keratoconjunctivitis sicca. However, patients with low Schirmer test scores uniformly preferred a solution containing chondroitin sulfate, while patients with moderate Schirmer test scores tended to prefer a solution of polyvinyl alcohol or hyaluronic acid.
20名患有干眼症的患者分别使用了三种不同的粘弹性泪液制剂和一种聚乙烯醇人工泪液，每种使用两周。在一项对照双盲研究中，每清醒两小时使用一次每种制剂。18名患者报告称，在瘙痒、灼烧感和异物感的严重程度方面，在研究过程中有显著改善。有这些表现的患者角膜染色和黏液丝形成也有所减少。大多数患者没有偏好任何一种制剂，也没有一种制剂在治疗干眼症体征方面被证明更具优势。然而，泪液分泌试验得分低的患者一致更喜欢含有硫酸软骨素的溶液，而泪液分泌试验得分中等的患者倾向于更喜欢聚乙烯醇或透明质酸溶液。
