Matossian Cynthia, Trattler William, Loh Jennifer
Matossian Eye Associates, Pennington, NJ, USA.
Center for Excellence in Eye Care, Miami, FL, USA.
Clin Ophthalmol. 2021 May 11;15:1979-1984. doi: 10.2147/OPTH.S308088. eCollection 2021.
To evaluate the efficacy of topical cyclosporine 0.1% in chondroitin sulfate emulsion for the treatment of dry eye.
This retrospective multicenter study included 100 eyes of 50 dry eye patients aged ≥18 years, with preoperative ocular surface disease index (OSDI) score >12 or corneal staining grade >1 (in either eye) who underwent dry eye treatment with topical cyclosporine 0.1% in chondroitin sulfate emulsion (Klarity-C, ImprimisRx) for 3 months. Postoperative evaluation included comparison of the changes in OSDI score and corneal staining grade after 3 months of treatment from baseline.
From baseline to 3 months, a statistically significant improvement in mean OSDI scores (38.19 vs 24.18, p <0.001) as well as mean corneal staining grade (3.62 vs 2.20, p <0.001) was observed. The proportion of subjects with severe dry eye decreased from 62% to 20% and more than one-third (34%) of patients were in the normal OSDI range. The percentage of eyes with corneal staining grade of 2 or 3 decreased from 21% (baseline) to 8% at 3 months; 50% of the eyes had corneal staining grade of 0. The treatment was found to be safe with no adverse events observed in the study.
Dry eye treatment with twice daily cyclosporine 0.1% in chondroitin sulfate emulsion was found to be safe and effective in reducing signs and symptoms of dry eye.
评估0.1%环孢素硫酸软骨素乳剂局部治疗干眼症的疗效。
这项回顾性多中心研究纳入了50例年龄≥18岁的干眼症患者的100只眼，这些患者术前眼表疾病指数（OSDI）评分>12或角膜染色分级>1（任一眼），接受0.1%环孢素硫酸软骨素乳剂（Klarity-C，ImprimisRx）局部治疗干眼症3个月。术后评估包括比较治疗3个月后OSDI评分和角膜染色分级相对于基线的变化。
从基线到3个月，平均OSDI评分（38.19对24.18，p<0.001）以及平均角膜染色分级（3.62对2.20，p<0.001）均有统计学意义的改善。重度干眼症患者比例从62%降至20%，超过三分之一（34%）的患者OSDI处于正常范围。角膜染色分级为2或3的眼的百分比从基线时的21%降至3个月时的8%；50%的眼角膜染色分级为0。研究发现该治疗安全，未观察到不良事件。
每天两次使用0.1%环孢素硫酸软骨素乳剂治疗干眼症在减轻干眼症的体征和症状方面安全有效。
