Hauss J, Spiegel H U, Schönleben K, Bünte H
Angiology. 1987 Jan;38(1 Pt 1):13-21. doi: 10.1177/000331978703800102.
Hypoxic and ischemic states are the main problem makers in angiology and vascular surgery. It is therefore suggestive to employ the technique of tissue-pO2 measurement for the verification and support of diagnostic and therapeutic measures. Two forms of registration are possible: continuous monitoring of partial oxygen pressures in eight different places and registration in the form of pO2-histograms, which represents a kind of "representative opinion poll" held in the tissue. The effects of a surgical intervention (endarterectomy, bypass operation) and the efficacy of blood flow-promoting drugs were studied in several series. In 9 patients the effect of the blood flow-promoting agent pentoxifylline (3,7-dimethyl-1-(5-oxohexyl)-xanthine) was studied. The pO2-histograms exhibited a shift to the right by an average of 7 mmHg after administration of this drug. Moreover, findings obtained with sodium nitroprusside and nitroglycerin during induced hypotension indicate that the continuous measuring of tissue-pO2 and recording of oxygen pressure distribution curves (pO2-histogram) provide the clinician with essential guidance data for the improvement of diagnostics and therapeutic control.
缺氧和缺血状态是血管病学和血管外科中的主要问题根源。因此，采用组织氧分压测量技术来验证和支持诊断及治疗措施是很有必要的。有两种记录形式：连续监测八个不同部位的局部氧分压，以及以氧分压直方图的形式记录，这代表了在组织中进行的一种“代表性民意调查”。在几个系列研究中，对手术干预（动脉内膜切除术、搭桥手术）的效果以及促进血流药物的疗效进行了研究。对9名患者研究了促进血流药物己酮可可碱（3,7 - 二甲基 - 1 - (5 - 氧代己基) - 黄嘌呤）的效果。给予该药物后，氧分压直方图平均向右移动了7 mmHg。此外，在诱导性低血压期间使用硝普钠和硝酸甘油的研究结果表明，连续测量组织氧分压并记录氧压分布曲线（氧分压直方图）为临床医生改善诊断和治疗控制提供了重要的指导数据。
