Kiaer T, Grønlund J, Jensen B, Svalastoga E
Department of Physiology, Odense University, Denmark.
J Orthop Res. 1990 Jul;8(4):618-22. doi: 10.1002/jor.1100080419.
Several regulatory mechanisms have been shown to influence the intraosseous circulation. The influence of general hypovolemia on bone circulation and possible regulatory effects were investigated by recording the intraosseous pressure and PO2 and PCO2 continuously by mass spectrometry in rabbits. Hypovolemia was induced by repeated bleedings. The intraosseous and arterial pressures were found to be linearly related. The intraosseous PO2 already decreased after the first step of bleeding and decreased more than 50% of the initial value after an average blood loss of 40 ml. The intraosseous PCO2 showed an opposite pattern. The experimental PO2 vs. arterial pressure curves were similar to curves obtained by a computer simulation that assumes the blood flow to be proportional to the intraosseous pressure.
已有多种调节机制被证明可影响骨内循环。通过质谱法连续记录兔骨内压力、氧分压（PO2）和二氧化碳分压（PCO2），研究了全身血容量减少对骨循环的影响及其可能的调节作用。通过反复放血诱导血容量减少。发现骨内压与动脉压呈线性相关。放血第一步后骨内PO2就已降低，平均失血40毫升后，骨内PO2降低超过初始值的50%。骨内PCO2呈现相反的变化模式。实验中PO2与动脉压的曲线类似于通过计算机模拟获得的曲线，该模拟假设血流与骨内压成正比。
