Schultheiss R, Leuwer R, Leniger-Follert E, Wassmann H, Wüllenweber R
Angiology. 1987 Mar;38(3):221-5. doi: 10.1177/000331978703800303.
A polarographic multiwire surface electrode was used for measurement of local oxygen partial pressure (pO2) on human brain cortex during neurosurgical operations. The two major problems encountered in this application of the electrode involved sterility of the equipment and mounting of the electrode. The described method of sterilization does not alter the electrical properties of the electrode. A special mount was designed to allow free three-dimensional placement of the electrode without exerting pressure on the cortex. Basic results of this technique demonstrated that it is possible to distinguish different pO2 distribution patterns displayed in pO2 histograms for various types of brain tumors and edematous brain tissue. In patients with arteriovenous malformations (AVMs) of the brain, an increase of tissue pO2 in cortical areas adjacent to the AVM was the result of extirpation of the lesion. The effect of intravenously administered pentoxifylline was studied during extraintracranial bypass operations in patients with cerebrovascular disease. In 7 patients a consistent shift of the pO2 histograms to the right, i.e., to higher pO2 values, could be demonstrated. Mean pO2 values increased statistically significantly by 16 +/- 7 mmHg as early as ten minutes after infusion of pentoxifylline. The rapid improvement of tissue oxygenation of human brain cortex is thought to be the result of an improvement of microcirculation, for other parameters influencing tissue pO2 showed no significant alterations if any.
在神经外科手术期间，使用极谱多丝表面电极测量人脑皮质局部氧分压（pO2）。在该电极的此应用中遇到的两个主要问题涉及设备的无菌性和电极的安装。所描述的灭菌方法不会改变电极的电学性质。设计了一种特殊的固定装置，以允许电极在不向皮质施加压力的情况下进行自由的三维放置。该技术的基本结果表明，对于各种类型的脑肿瘤和脑水肿组织，能够区分pO2直方图中显示的不同pO2分布模式。在患有脑动静脉畸形（AVM）的患者中，AVM相邻皮质区域的组织pO2升高是病变切除的结果。在患有脑血管疾病的患者进行颅内外搭桥手术期间，研究了静脉注射己酮可可碱的效果。在7名患者中，可以证明pO2直方图一致地向右移动，即向更高的pO2值移动。早在输注己酮可可碱十分钟后，平均pO2值就有统计学意义地显著增加16±7 mmHg。人脑皮质组织氧合的快速改善被认为是微循环改善的结果，因为影响组织pO2的其他参数即使有变化也不显著。
