Harvard Medical School, Boston, 02115, USA.
Women and Children's Hospital, Shenzhen, 518052, China.
Curr Med Sci. 2019 Apr;39(2):173-184. doi: 10.1007/s11596-019-2016-4. Epub 2019 Apr 23.
The therapeutic potentials of probiotics in autism spectrum disorder (ASD) remains controversial, with the only existing systematic review on this topic published in 2015. Results from new trials have become available in recent years. We therefore conducted an updated systematic review, to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities. Our review includes two randomized controlled trials, which showed improvement of ASD behaviors, and three open trials, all which exhibited a trend of improvement. Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy. Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD.
益生菌在自闭症谱系障碍（ASD）中的治疗潜力仍然存在争议，关于这个主题的唯一现有系统评价发表于 2015 年。近年来，新的试验结果已经公布。因此，我们进行了更新的系统评价，以评估益生菌缓解 ASD 行为症状和胃肠道共病的疗效。我们的综述包括两项随机对照试验，结果显示 ASD 行为得到改善，以及三项开放试验，均显示出改善的趋势。其中四项试验从主观测量得出结论，益生菌治疗后胃肠道功能指标有改善的趋势。需要更多严格的试验来评估益生菌补充剂在 ASD 中的效果。
