Gou Xue-Ya, Li Yuke, Wang Xin-Gang, Liu Hong-Chao, Zhang Bo-Sheng, Zhao Jia-Hui, Zhou Zhao-Zhao, Liang Yong-Min
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Chem Commun (Camb). 2019 May 7;55(38):5487-5490. doi: 10.1039/c9cc02499a.
Application of an oxidative amination reagent (di-tert-butyldiaziridinone) to the Ru3(CO)12-catalyzed ortho-selective CAr-H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential for this methodology. Mechanistic studies showed that the reaction process involves an octahedral ruthenium species, and the carbon monoxide ligand plays a crucial role in the C-H activation.
