• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.上位性相互作用可以调节流感 H3N2 病毒血凝素中替换的抗原效应。
J Gen Virol. 2019 May;100(5):773-777. doi: 10.1099/jgv.0.001263. Epub 2019 Apr 24.
2
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.受体结合位点附近的替换决定了流感病毒进化过程中的主要抗原性变化。
Science. 2013 Nov 22;342(6161):976-9. doi: 10.1126/science.1244730.
3
The Molecular Determinants of Antibody Recognition and Antigenic Drift in the H3 Hemagglutinin of Swine Influenza A Virus.甲型猪流感病毒H3血凝素中抗体识别和抗原漂移的分子决定因素
J Virol. 2016 Aug 26;90(18):8266-80. doi: 10.1128/JVI.01002-16. Print 2016 Sep 15.
4
Predominance of influenza A(H3N2) viruses during the 2016/2017 season in Bulgaria.2016/2017年度保加利亚流感季节甲型（H3N2）病毒占主导地位。
J Med Microbiol. 2018 Feb;67(2):228-239. doi: 10.1099/jmm.0.000668. Epub 2018 Jan 3.
5
Molecular and antigenic characterization of the H3 hemagglutinin of H3N2 influenza A virus strains collected in the Czech Republic during the 2014/2015 epidemic season.2014/2015流行季在捷克共和国收集的甲型H3N2流感病毒株H3血凝素的分子和抗原特性
Epidemiol Mikrobiol Imunol. 2016 Summer;65(2):92-101.
6
Antigenic and genetic evolution of swine influenza A (H3N2) viruses in Europe.欧洲甲型流感病毒（H3N2）的抗原性和基因进化
J Virol. 2007 Apr;81(8):4315-22. doi: 10.1128/JVI.02458-06. Epub 2007 Feb 7.
7
Isolation of an Egg-Adapted Influenza A(H3N2) Virus without Amino Acid Substitutions at the Antigenic Sites of Its Hemagglutinin.一株血凝素抗原位点无氨基酸替换的鸡胚适应甲型流感病毒（H3N2）的分离
Jpn J Infect Dis. 2018 May 24;71(3):234-238. doi: 10.7883/yoken.JJID.2017.551. Epub 2018 Apr 27.
8
Characterization of an enhanced antigenic change in the pandemic 2009 H1N1 influenza virus haemagglutinin.2009年大流行H1N1流感病毒血凝素增强抗原性变化的特征
J Gen Virol. 2014 May;95(Pt 5):1033-1042. doi: 10.1099/vir.0.061598-0. Epub 2014 Feb 14.
9
Molecular and antigenic evolution of human influenza A/H3N2 viruses in Quebec, Canada, 2009-2011.2009-2011 年加拿大魁北克省人季节性 H3N2 流感病毒的分子和抗原进化。
J Clin Virol. 2012 Jan;53(1):88-92. doi: 10.1016/j.jcv.2011.09.016. Epub 2011 Oct 28.
10
Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation.中国 H3N2 流感抗原进化的研究揭示了疫苗株推荐的策略。
Nat Commun. 2012 Feb 28;3:709. doi: 10.1038/ncomms1710.

引用本文的文献

1
Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study.季节性流感疫苗接种后年轻人和老年人中血凝素表位变异及对连续A/维多利亚A(H1N1)毒株的抗体反应：一项初步研究
Vaccines (Basel). 2025 Jul 21;13(7):774. doi: 10.3390/vaccines13070774.
2
Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment.免疫功能低下个体体内人类诺如病毒的宿主内进化模式及其治疗意义。
EBioMedicine. 2024 Nov;109:105391. doi: 10.1016/j.ebiom.2024.105391. Epub 2024 Oct 12.
3
Seasonal antigenic prediction of influenza A H3N2 using machine learning.基于机器学习的季节性 A(H3N2)型流感抗原预测。
Nat Commun. 2024 May 7;15(1):3833. doi: 10.1038/s41467-024-47862-9.
4
Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail ().使用来自鹌鹑（）的血清对 H9 亚型流感 A 病毒的血凝素进行抗原作图。
J Virol. 2023 Oct 31;97(10):e0074323. doi: 10.1128/jvi.00743-23. Epub 2023 Oct 6.
5
Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape.上位性降低了 SARS-CoV-2 中和抗体逃逸的遗传屏障。
Nat Commun. 2023 Jan 19;14(1):302. doi: 10.1038/s41467-023-35927-0.
6
Serial Passaging of Seasonal H3N2 Influenza A/Singapore/G2-31.1/2014 Virus in MDCK-SIAT1 Cells and Primary Chick Embryo Cells Generates HA D457G Mutation and Other Variants in HA, NA, PB1, PB1-F2, and NS1.季节性 H3N2 流感 A/Singapore/G2-31.1/2014 病毒在 MDCK-SIAT1 细胞和原代鸡胚细胞中的连续传代产生了 HA D457G 突变和 HA、NA、PB1、PB1-F2 和 NS1 中的其他变异。
Int J Mol Sci. 2022 Oct 17;23(20):12408. doi: 10.3390/ijms232012408.
7
Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution.人类 H3N2 流感病毒的蛋适应性突变取决于自然进化。
PLoS Pathog. 2022 Sep 26;18(9):e1010875. doi: 10.1371/journal.ppat.1010875. eCollection 2022 Sep.
8
Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing.人季节性 H3N2 流感神经氨酸酶的抗原进化受到电荷平衡的限制。
Elife. 2021 Dec 8;10:e72516. doi: 10.7554/eLife.72516.
9
A statistical analysis of antigenic similarity among influenza A (H3N2) viruses.甲型流感病毒（H3N2）抗原相似性的统计分析
Heliyon. 2021 Nov 12;7(11):e08384. doi: 10.1016/j.heliyon.2021.e08384. eCollection 2021 Nov.
10
The Ecology and Evolution of Influenza Viruses.流感病毒的生态学与进化。
Cold Spring Harb Perspect Med. 2020 Jul 1;10(7):a038489. doi: 10.1101/cshperspect.a038489.

本文引用的文献

1
A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.一个复杂的上位网络限制了流感血凝素受体结合位点的突变可逆性。
Nat Commun. 2018 Mar 28;9(1):1264. doi: 10.1038/s41467-018-03663-5.
2
Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.流感血凝素受体结合位点中功能允许序列的多样性。
Cell Host Microbe. 2017 Jun 14;21(6):742-753.e8. doi: 10.1016/j.chom.2017.05.011.
3
The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans.有害突变负荷对甲型H3N2流感病毒在人类中抗原进化模式的影响。
Elife. 2015 Sep 15;4:e07361. doi: 10.7554/eLife.07361.
4
Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution.受体结合位点附近的替换决定了流感病毒进化过程中的主要抗原性变化。
Science. 2013 Nov 22;342(6161):976-9. doi: 10.1126/science.1244730.
5
Immune history shapes specificity of pandemic H1N1 influenza antibody responses.免疫史塑造了大流行性 H1N1 流感抗体反应的特异性。
J Exp Med. 2013 Jul 29;210(8):1493-500. doi: 10.1084/jem.20130212. Epub 2013 Jul 15.
6
Single hemagglutinin mutations that alter both antigenicity and receptor binding avidity influence influenza virus antigenic clustering.单一的血凝素突变可以同时改变抗原性和受体结合亲和力，从而影响流感病毒的抗原聚类。
J Virol. 2013 Sep;87(17):9904-10. doi: 10.1128/JVI.01023-13. Epub 2013 Jul 3.
7
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.通过连续的单克隆抗体选择定义甲型流感病毒血凝素抗原漂移。
Cell Host Microbe. 2013 Mar 13;13(3):314-23. doi: 10.1016/j.chom.2013.02.008.
8
Prevalence of epistasis in the evolution of influenza A surface proteins.甲型流感表面蛋白进化中的上位性现象。
PLoS Genet. 2011 Feb;7(2):e1001301. doi: 10.1371/journal.pgen.1001301. Epub 2011 Feb 17.
9
Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift.血凝素受体结合亲和力驱动甲型流感病毒抗原漂移。
Science. 2009 Oct 30;326(5953):734-6. doi: 10.1126/science.1178258.
10
STUDIES OF ANTIGENIC DIFFERENCES AMONG STRAINS OF INFLUENZA A BY MEANS OF RED CELL AGGLUTINATION.流感 A 株间抗原差异的研究——红细胞凝集法。
J Exp Med. 1943 Nov 1;78(5):407-23. doi: 10.1084/jem.78.5.407.

上位性相互作用可以调节流感 H3N2 病毒血凝素中替换的抗原效应。

Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus.

机构信息

1 Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.

2 Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK.

出版信息

J Gen Virol. 2019 May;100(5):773-777. doi: 10.1099/jgv.0.001263. Epub 2019 Apr 24.

DOI:10.1099/jgv.0.001263
PMID:31017567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7176280/
Abstract

We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antigenic effect of substitutions introduced at haemagglutinin position 145 was fully independent of the amino acid context of the representative haemagglutinins. Antigenic change caused by substitutions introduced at haemagglutinin position 155 was variable and context-dependent. Our results suggest that epistatic interactions with contextual amino acids in the haemagglutinin can moderate the magnitude of antigenic change.

摘要

我们之前的研究表明，血凝素（hemagglutinin）七个位置的单个氨基酸取代决定了流感 H3N2 病毒的主要抗原性变化。在这里，我们在 11 种具有代表性的 H3 血凝素中测试了这两种取代的影响，以研究上下文相关效应。在血凝素位置 145 引入的取代的抗原效应完全独立于代表性血凝素的氨基酸上下文。在血凝素位置 155 引入的取代引起的抗原变化是可变的和上下文相关的。我们的研究结果表明，与血凝素中上下文氨基酸的上位效应相互作用可以调节抗原性变化的幅度。