Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2019 Jun;35(6):327-331. doi: 10.1002/kjm2.12069. Epub 2019 Apr 24.
Fecal microbiota transplantation (FMT) had been an ancient remedy for severe illness several centuries ago. Under modern medical analysis and evidence-based research, it has been proved as an alternative treatment for recurrent Clostridium difficile infection and recent randomized control study also showed that FMT could be an adjuvant treatment for inflammatory bowel disease. As we get a better understanding of the relationship between gut microbiota and systemic disease, FMT became a potential treatment to explore. This article summarized procedures such as donor selection, fecal material preparation, transplantation delivery methods, and adverse events. We also review the present evidence about FMT in clinical practice.
粪便微生物群移植（FMT）在几个世纪前曾是一种治疗严重疾病的古老方法。在现代医学分析和基于证据的研究下，它已被证明是复发性艰难梭菌感染的一种替代治疗方法，最近的随机对照研究也表明 FMT 可以作为炎症性肠病的辅助治疗方法。随着我们对肠道微生物群与全身疾病之间关系的了解不断加深，FMT 成为一种有潜力的治疗方法。本文总结了供体选择、粪便材料准备、移植传递方法和不良反应等程序。我们还回顾了 FMT 在临床实践中的现有证据。
