Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, People's Republic of China.
Multidisciplinary Team (MDT) for Geriatric Hip Fracture Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People's Republic of China.
J Bone Miner Metab. 2022 Nov;40(6):874-889. doi: 10.1007/s00774-022-01375-x. Epub 2022 Nov 11.
Osteoporosis is a systemic metabolic bone disease characterized by the descending bone mass and destruction of bone microstructure, which tends to result in the increased bone fragility and associated fractures, as well as high disability rate and mortality. The relation between gut microbiota and bone metabolism has gradually become a research hotspot, and it has been verified that gut microbiota is closely associated with reduction of bone mass and incidence of osteoporosis recently. As a novel "organ transplantation" technique, fecal microbiota transplantation (FMT) mainly refers to the transplantation of gut microbiota from healthy donors to recipients with gut microbiota imbalance, so that the gut microbiota in recipients can be reshaped and play a normal function, and further prevent or treat the diseases related to gut microbiota disorder. Herein, based on the gut-bone axis and proven regulatory effects of gut microbiota on osteoporosis, this review expounds relevant basic researches and clinical practice of FMT on osteoporosis, thus demonstrating the potentials of FMT as a therapeutic option for osteoporosis and further providing certain reference for the future researches.
骨质疏松症是一种以骨量下降和骨微观结构破坏为特征的全身性代谢性骨病，易导致骨脆性增加和相关骨折，以及高残疾率和死亡率。肠道微生物群与骨代谢的关系逐渐成为研究热点，最近已经证实肠道微生物群与骨量减少和骨质疏松症的发生密切相关。粪便微生物群移植（FMT）作为一种新型的“器官移植”技术，主要是指将健康供体的肠道微生物群移植到肠道微生物群失衡的受者体内，使受者体内的肠道微生物群得以重塑并发挥正常功能，从而预防或治疗与肠道微生物群紊乱相关的疾病。在此，基于肠道-骨骼轴以及肠道微生物群对骨质疏松症的已证实的调节作用，本文阐述了 FMT 在骨质疏松症方面的相关基础研究和临床实践，展示了 FMT 作为骨质疏松症治疗选择的潜力，并为未来的研究提供了一定的参考。
