Han Yeo Ok, Jeong Yunju, You Hyun Ju, Ku Seockmo, Ji Geun Eog, Park Myeong Soo
Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea.
Research Center, BIFIDO Co., Ltd., Hongcheon 25117, Korea.
Microorganisms. 2019 Apr 23;7(4):108. doi: 10.3390/microorganisms7040108.
Rotavirus infection is the most common diarrheal disease worldwide in children under five years of age, and it often results in death. In recent years, research on the relationship between rotavirus and probiotics has shown that probiotics are effective against diarrhea. A clinical trial has reported that BORI reduced diarrhea induced by rotavirus. The present work investigated the anti-rotaviral effect of BORI by cytopathic effect observation and real time cell analyses. Our study found that BORI showed strong anti-rotaviral effect when incubated with MA104 cells prior to viral infection, suggesting that the probiotic does in fact interfere with the interaction of viruses and host cells. It is believed that the efficacy is due to low-molecular weight and non-protein components derived from BORI. This discovery can help broaden the industrial application of BORI, which has been proven to be a safe and effective probiotic.
轮状病毒感染是全球五岁以下儿童中最常见的腹泻病，且常常导致死亡。近年来，关于轮状病毒与益生菌之间关系的研究表明，益生菌对腹泻有效。一项临床试验报告称，BORI可减轻轮状病毒引起的腹泻。本研究通过细胞病变效应观察和实时细胞分析，对BORI的抗轮状病毒作用进行了研究。我们的研究发现，在病毒感染前将BORI与MA104细胞一起孵育时，BORI显示出强大的抗轮状病毒作用，这表明该益生菌实际上确实会干扰病毒与宿主细胞之间的相互作用。据信，其功效归因于源自BORI的低分子量和非蛋白质成分。这一发现有助于拓宽BORI的工业应用，BORI已被证明是一种安全有效的益生菌。
