The Anti-Rotaviral Activity of Low Molecular Weight and Non-Proteinaceous Substance from BORI Cell Extract.

Rotavirus infection is the most common diarrheal disease worldwide in children under five years of age, and it often results in death. In recent years, research on the relationship between rotavirus and probiotics has shown that probiotics are effective against diarrhea. A clinical trial has reported that BORI reduced diarrhea induced by rotavirus. The present work investigated the anti-rotaviral effect of BORI by cytopathic effect observation and real time cell analyses. Our study found that BORI showed strong anti-rotaviral effect when incubated with MA104 cells prior to viral infection, suggesting that the probiotic does in fact interfere with the interaction of viruses and host cells. It is believed that the efficacy is due to low-molecular weight and non-protein components derived from BORI. This discovery can help broaden the industrial application of BORI, which has been proven to be a safe and effective probiotic.