渗透胁迫诱导绒毛外滋养层细胞凋亡。TRPV-1 的作用。
Osmotic stress induces apoptosis in extravillous trophoblast cells. Role of TRPV-1.
机构信息
Laboratorio de Biología de La Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO)- CONICET- Facultad de Medicina, Universidad de Buenos Aires. Buenos Aires, Argentina.
Laboratorio de Fisiopatología Placentaria, (CEFYBO)-CONICET, Facultad de Medicina, Universidad de Buenos Aires. Buenos Aires, Argentina.
出版信息
Biochem Biophys Res Commun. 2019 Jun 18;514(1):58-63. doi: 10.1016/j.bbrc.2019.04.091. Epub 2019 Apr 21.
In different tissues hyperosmolarity induces cell differentiation. Nevertheless an exacerbated hyperosmolar stress alters the normal cellular development. The transient receptor potential vanilloid 1 (TRPV-1) is a non-selective cation channel that is activated by hyperosmolarity and participates in many cellular processes. TPRV-1 is expressed in human placenta at term. Here, we evaluated the expression of TRPV-1 in first trimester extravillous trophoblast cells and its participation in the survival of these cells exposed to hyperosmolar stress. Our results showed that hyperosmolar stress up-regulates the expression of TRPV-1 and induces the apoptosis in Swan 71 cells. In addition, the inhibition of TRPV-1 abrogates the apoptotic events.
在不同的组织中，高渗诱导细胞分化。然而，过度的高渗应激会改变正常的细胞发育。瞬时受体电位香草醛 1 型（TRPV-1）是一种非选择性阳离子通道，可被高渗激活，并参与许多细胞过程。TRPV-1 在足月人胎盘组织中表达。在这里，我们评估了 TRPV-1 在早孕期绒毛外滋养层细胞中的表达及其在这些细胞暴露于高渗应激时存活中的作用。结果表明，高渗应激可上调 TRPV-1 的表达并诱导 Swan 71 细胞凋亡。此外，TRPV-1 的抑制可阻断凋亡事件。
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