重症监护病房中丙泊酚输注用于镇静：初步报告。
Propofol infusion for sedation in the intensive care unit: preliminary report.
作者信息
Grounds R M, Lalor J M, Lumley J, Royston D, Morgan M
出版信息
Br Med J (Clin Res Ed). 1987 Feb 14;294(6569):397-400. doi: 10.1136/bmj.294.6569.397.
Abstract
Propofol (2,6,di-isopropylphenol) was given by continuous intravenous infusion to provide sedation after cardiac surgery in 30 patients and its effects compared with those of midazolam given to a further 30 patients. Propofol infusion allowed rapid and accurate control of the level of sedation, which was satisfactory for longer than with midazolam. Patients given propofol recovered significantly more rapidly from their sedation once they had fulfilled the criteria for weaning from artificial ventilation and as a result spent a significantly shorter time attached to a ventilator. There were no serious complications in either group. Both medical and nursing staff considered the propofol infusion to be superior to midazolam in these patients. These findings suggest that propofol is a suitable replacement for etomidate and alphaxalone-alphadolone for sedating patients receiving intensive care.
摘要
对30例心脏手术后的患者持续静脉输注丙泊酚（2,6 - 二异丙基苯酚）以提供镇静，并将其效果与另外30例接受咪达唑仑治疗的患者进行比较。输注丙泊酚能快速、准确地控制镇静水平，且比咪达唑仑维持满意镇静水平的时间更长。一旦符合撤机标准，接受丙泊酚治疗的患者从镇静状态中恢复得明显更快，因此使用呼吸机的时间显著缩短。两组均未出现严重并发症。医护人员均认为在这些患者中丙泊酚输注优于咪达唑仑。这些发现表明，丙泊酚是用于重症监护患者镇静的依托咪酯和α - 羟孕酮 - α - 羟孕烷二酮的合适替代药物。
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