用α-羟孕酮-孕二酮进行控制性镇静。
Controlled sedation with alphaxalone-alphadolone.
作者信息
Ramsay M A, Savege T M, Simpson B R, Goodwin R
出版信息
Br Med J. 1974 Jun 22;2(5920):656-9. doi: 10.1136/bmj.2.5920.656.
Abstract
Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided "light sleep," allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.
摘要
将阿法沙龙-阿法多龙（阿尔泰辛）稀释后作为控制输注药物，用于重症监护病房的30例患者作为镇静剂。这种技术能快速、准确地控制镇静水平。它有三个特别有用的用途：提供“浅睡眠”，允许镇静水平快速变化，并能对中枢神经系统进行反复评估。在总时长的86%时间里镇静效果令人满意，且未发现因使用该药物导致的严重并发症。此外，尽管阿法沙龙-阿法多龙的给药时间长达20天，但没有证据表明出现快速耐受性或恢复时间延迟。
相似文献
1
Controlled sedation with alphaxalone-alphadolone.用α-羟孕酮-孕二酮进行控制性镇静。
Br Med J. 1974 Jun 22;2(5920):656-9. doi: 10.1136/bmj.2.5920.656.
2
Propofol infusion for sedation in the intensive care unit: preliminary report.重症监护病房中丙泊酚输注用于镇静：初步报告。
Br Med J (Clin Res Ed). 1987 Feb 14;294(6569):397-400. doi: 10.1136/bmj.294.6569.397.
3
Clinical trial of continuous infusion of alphaxalone/alphadolone in intensive care patients.
Anaesth Intensive Care. 1983 May;11(2):107-12. doi: 10.1177/0310057X8301100203.
4
Clinical studies with althesin (CT 1341) in minor operative procedures.
S Afr Med J. 1973 Jan 27;47(4):129-32.
5
Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically.
Br J Anaesth. 2001 May;86(5):704-8. doi: 10.1093/bja/86.5.704.
6
Clinical studies of induction agents. XLII: Influence of injection rate and dosage on the induction complications with Althesin.
Br J Anaesth. 1973 Dec;45(12):1215-6. doi: 10.1093/bja/45.12.1215.
7
A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit.一项评估右美托咪定在医学重症监护病房用于镇静效果的II期研究。
Intensive Care Med. 2003 Feb;29(2):201-7. doi: 10.1007/s00134-002-1579-9. Epub 2002 Nov 22.
8
Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs.犬卵巢子宫切除术全静脉麻醉中阿法沙龙与丙泊酚的比较。
Vet Anaesth Analg. 2012 May;39(3):236-44. doi: 10.1111/j.1467-2995.2011.00700.x. Epub 2012 Mar 8.
9
EFFICACY AND SAFETY OF A MEDETOMIDINE-AZAPERONE-ALFAXALONE COMBINATION IN CAPTIVE WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS).美托咪定-阿扎哌隆-阿法沙龙组合在圈养白尾鹿（弗吉尼亚鹿）中的有效性和安全性
J Zoo Wildl Med. 2016 Mar;47(1):29-37. doi: 10.1638/2015-0121.1.
10
Alphaxalone/alphadolone anaesthesia in the lamb.
Vet Rec. 1982 Mar 20;110(12):273-5. doi: 10.1136/vr.110.12.273.
引用本文的文献
1
Predicting Episodes of Hypovigilance in Intensive Care Units Using Routine Physiological Parameters and Artificial Intelligence: Derivation Study.使用常规生理参数和人工智能预测重症监护病房的警觉性降低发作：推导研究
JMIR AI. 2025 Aug 27;4:e60885. doi: 10.2196/60885.
2
Evaluation of Objective Sedation Monitoring Practices in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis.危重症成年患者客观镇静监测实践的评估：一项系统评价和荟萃分析
Crit Care Explor. 2025 Aug 11;7(8):e1297. doi: 10.1097/CCE.0000000000001297. eCollection 2025 Aug 1.
3
Evaluation of different sedation scales in the ICU management of COVID-19 patients.新冠病毒肺炎患者重症监护病房管理中不同镇静评分的评估
Sci Rep. 2025 Aug 6;15(1):28782. doi: 10.1038/s41598-025-14421-1.
4
Methadone for critically ill patients under mechanical ventilation in the intensive care unit: a systematic review.重症监护病房中接受机械通气的重症患者使用美沙酮：一项系统评价。
Crit Care Sci. 2025 Aug 4;37:e20250396. doi: 10.62675/2965-2774.20250396. eCollection 2025.
5
Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial.艾氯胺酮预防输尿管镜碎石术后导尿管相关膀胱不适的随机对照试验
BMC Anesthesiol. 2025 Jul 29;25(1):361. doi: 10.1186/s12871-025-03236-2.
6
Procedural Pain Management in Patients with Cerebral Palsy Undergoing Botulinum Toxin Injection: A Systematic Review and Meta-Analysis.接受肉毒杆菌毒素注射的脑瘫患者的程序性疼痛管理：系统评价和荟萃分析
Toxins (Basel). 2025 Jun 22;17(7):317. doi: 10.3390/toxins17070317.
7
Efficacy of Oral Midazolam for Sedation and Amnesia in Preschool Children with Dental Anxiety: A Double-Blind, Randomized Controlled Trial.口服咪达唑仑对牙科焦虑学龄前儿童镇静和遗忘的疗效：一项双盲随机对照试验
Dent J (Basel). 2025 Jul 9;13(7):308. doi: 10.3390/dj13070308.
8
Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study).比较苯二氮䓬-氯胺酮与苯二氮䓬-芬太尼在白内障超声乳化术中的镇静效果：一项双盲交叉非劣效性临床试验（BEKEF研究）。
Adv Ophthalmol Pract Res. 2025 Apr 3;5(3):175-179. doi: 10.1016/j.aopr.2025.04.001. eCollection 2025 Aug-Sep.
9
Midazolam for sedation of infants in the neonatal intensive care unit.咪达唑仑用于新生儿重症监护病房中婴儿的镇静。
Cochrane Database Syst Rev. 2025 Jul 17;7(7):CD002052. doi: 10.1002/14651858.CD002052.pub4.
10
Dexmedetomidine combined with propofol improves hemodynamic stability and recovery in elderly patients undergoing thoracoscopic lung cancer resection.右美托咪定联合丙泊酚可改善老年胸腔镜肺癌切除术患者的血流动力学稳定性及恢复情况。
Am J Transl Res. 2025 Jun 15;17(6):4409-4420. doi: 10.62347/XCOK4904. eCollection 2025.
本文引用的文献
1
Effect of althesin on cerebral perfusion, cerebral metabolism and intracranial pressure in the anaesthetized baboon.阿法沙龙对麻醉狒狒脑灌注、脑代谢及颅内压的影响。
Br J Anaesth. 1972 Aug;44(8):751-7. doi: 10.1093/bja/44.8.751.
2
Alterations in response to somatic pain associated with anaesthesia. XXI. Althesin (CT1341).
Br J Anaesth. 1972 Jun;44(6):590-2. doi: 10.1093/bja/44.6.590.
3
Influence of subnarcotic doses of Althesin (CT1341) on pain induced by two types of pain stimulus.
Br J Anaesth. 1973 May;45(5):481-5. doi: 10.1093/bja/45.5.481.
4
The effect of althesin on intracranial pressure in man.阿法沙龙对人体颅内压的影响。
Br J Anaesth. 1973 Feb;45(2):168-72. doi: 10.1093/bja/45.2.168.
Zotero 插件