Hadházy P, Magyar K
Br J Pharmacol. 1986 Dec;89(4):861-3. doi: 10.1111/j.1476-5381.1986.tb11192.x.
Indomethacin potentiated noradrenaline (NA)-induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1-1.0 mumol l-1) and inhibited by indomethacin in a concentration-dependent manner. There was a positive correlation between the indomethacin-induced inhibition of PGI2 formation and the indomethacin-evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone.
吲哚美辛增强去甲肾上腺素(NA)诱导的兔离体肠系膜动脉收缩。机械去除内皮不影响其增强作用。NA(0.1 - 1.0 μmol l-1)刺激前列环素(PGI2)合成,吲哚美辛以浓度依赖方式抑制其合成。吲哚美辛诱导的PGI2形成抑制与吲哚美辛引起的对NA收缩反应增强之间存在正相关。这些结果表明内源性PGI2在血管平滑肌张力的反馈控制中起作用。