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动脉平滑肌张力的反馈控制：前列环素的作用。

Feedback control of arterial smooth muscle tone: the role of prostacyclin.

作者信息

Hadházy P, Magyar K

出版信息

Br J Pharmacol. 1986 Dec;89(4):861-3. doi: 10.1111/j.1476-5381.1986.tb11192.x.

DOI:10.1111/j.1476-5381.1986.tb11192.x
PMID:3101929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917248/
Abstract

Indomethacin potentiated noradrenaline (NA)-induced contractions of rabbit isolated mesenteric arteries. Mechanical removal of the endothelium did not influence its potentiating effect. Prostacyclin (PGI2) synthesis was stimulated by NA (0.1-1.0 mumol l-1) and inhibited by indomethacin in a concentration-dependent manner. There was a positive correlation between the indomethacin-induced inhibition of PGI2 formation and the indomethacin-evoked potentiation of contractile responses to NA. These results suggest that endogenous PGI2 plays a part in the feedback control of vascular smooth muscle tone.

摘要

吲哚美辛增强去甲肾上腺素（NA）诱导的兔离体肠系膜动脉收缩。机械去除内皮不影响其增强作用。NA（0.1 - 1.0 μmol l-1）刺激前列环素（PGI2）合成，吲哚美辛以浓度依赖方式抑制其合成。吲哚美辛诱导的PGI2形成抑制与吲哚美辛引起的对NA收缩反应增强之间存在正相关。这些结果表明内源性PGI2在血管平滑肌张力的反馈控制中起作用。

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1
Feedback control of arterial smooth muscle tone: the role of prostacyclin.动脉平滑肌张力的反馈控制：前列环素的作用。
Br J Pharmacol. 1986 Dec;89(4):861-3. doi: 10.1111/j.1476-5381.1986.tb11192.x.
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引用本文的文献

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Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):500-15. doi: 10.1007/s00210-005-1065-3. Epub 2005 Jul 13.

本文引用的文献

1
Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins, I2, E2, and F2 alpha from te perfused mesenteric arterial bed of the rabbit.神经刺激以及去甲肾上腺素或氯化钾给药对兔肠系膜动脉床灌注液中前列腺素I2、E2和F2α释放的影响。
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2
Prostacyclin production by cultured smooth muscle cells from atherosclerotic rabbit aorta.来自动脉粥样硬化兔主动脉的培养平滑肌细胞产生前列环素。
Nature. 1980 Jun 12;285(5765):480-2. doi: 10.1038/285480a0.
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Effect of angiotensin ii and norepinephrine on release of prostaglandins E2 and I2 by the perfused rat mesenteric artery.血管紧张素II和去甲肾上腺素对灌注大鼠肠系膜动脉释放前列腺素E2和I2的影响。
Prostaglandins. 1982 Jul;24(1):105-14. doi: 10.1016/0090-6980(82)90182-4.
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Differential contractile responsiveness of isolated rabbit arteries from different vascular beds to cyclooxygenase inhibitors and PGI2.来自不同血管床的离体兔动脉对环氧合酶抑制剂和前列环素（PGI2）的收缩反应差异。
Eur J Pharmacol. 1984 Mar 2;98(3-4):323-30. doi: 10.1016/0014-2999(84)90280-2.
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The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels.除前列环素外的内源性前列腺素对某些兔血管收缩性调节的重要性。
Br J Pharmacol. 1984 Apr;81(4):623-30. doi: 10.1111/j.1476-5381.1984.tb16127.x.
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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.内皮细胞在乙酰胆碱介导的动脉平滑肌舒张中所起的不可或缺的作用。
Nature. 1980 Nov 27;288(5789):373-6. doi: 10.1038/288373a0.
7
Modification by prostaglandins E1 and E2, indomethacin, and arachidonic acid of the vasoconstrictor responses of the isolated perfused rabbit and rat mesenteric arteries to adrenergic stimuli.前列腺素E1、E2、消炎痛和花生四烯酸对离体灌注兔和大鼠肠系膜动脉对肾上腺素能刺激的血管收缩反应的影响。
Circ Res. 1976 Aug;39(2):163-8. doi: 10.1161/01.res.39.2.163.
8
Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts.培养的人动脉平滑肌细胞、静脉内皮细胞和皮肤成纤维细胞中前列环素合成的特性研究
Cell. 1979 Apr;16(4):967-74. doi: 10.1016/0092-8674(79)90111-9.