Pandey Deeksha, Solleti Vani, Jain Gazal, Das Anwesha, Shama Prasada Kabekkodu, Acharya Shobha, Satyamoorthy Kapaettu
Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
School of Life Sciences, Manipal Academy of Higher Education, Manipal, India.
Infect Dis Obstet Gynecol. 2019 Mar 24;2019:4376902. doi: 10.1155/2019/4376902. eCollection 2019.
Young women (20-35 years) are at high risk of HPV infection, although the majority of the infections are asymptomatic and are cleared spontaneously by the host immune system. These are also the group of women who are sexually active and are in the population of pregnant women. During pregnancy, the changes in the hormonal milieu and immune response may favor persistence of HPV infection and may aid in transgenerational transmission thereby furthering the cancer risk. In the present study, we determined the prevalence of vaginal HPV infection in early pregnancy and attempted to relate with pregnancy outcome.
Vaginal cytology samples were collected from the condoms used to cover the vaginal sonography probe during a routine first trimester visit to the hospital. All women were followed up throughout pregnancy and childbirth. Maternal and neonatal outcomes were recorded.
We found a prevalence of HPV infection around 39.4% in our population. Interestingly all HPV positive women were infected with one or more high risk HPV viruses with an overlap of intermediate and low risk in 43% and 7.3%, respectively. Women with preterm prelabor rupture of membranes (PPROM) showed a statistically higher incidence in HPV positive (7.3%) group as compared to the HPV negative (3.2%) group.
The prevalence of genital HPV infection is high during pregnancy (around 40%) and was associated with higher incidence of PPROM.
年轻女性（20 - 35岁）感染人乳头瘤病毒（HPV）的风险很高，尽管大多数感染是无症状的，且可被宿主免疫系统自发清除。这些女性也是性活跃群体，且包含在孕妇群体中。在怀孕期间，激素环境和免疫反应的变化可能有利于HPV感染的持续存在，并可能有助于跨代传播，从而增加患癌风险。在本研究中，我们确定了妊娠早期阴道HPV感染的患病率，并试图将其与妊娠结局相关联。
在医院进行常规孕早期检查时，从用于覆盖阴道超声探头的避孕套上收集阴道细胞学样本。所有女性在整个孕期及分娩过程中均接受随访。记录母婴结局。
我们发现研究人群中HPV感染的患病率约为39.4%。有趣的是，所有HPV阳性女性均感染了一种或多种高危HPV病毒，分别有43%和7.3%的女性同时感染了中危和低危HPV病毒。胎膜早破（PPROM）的女性在HPV阳性组（7.3%）中的发生率在统计学上高于HPV阴性组（3.2%）。
孕期生殖器HPV感染的患病率很高（约40%），且与PPROM的较高发生率相关。
