Faculty of Medicine, Vilnius University, M. K. Čiurlionio Str. 21, 03101 Vilnius, Lithuania.
Arch Gynecol Obstet. 2011 Nov;284(5):1105-12. doi: 10.1007/s00404-010-1787-4. Epub 2010 Dec 18.
Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. It has been established that about 70% of the sexually active population are exposed to this infection. The HPV prevalence rate among pregnant women ranges from 5.5 to 65.0%. Studies on HPV infection in pregnant women have yielded inconsistent results, including HPV prevalence, and HPV clearance.
Our aim is to determine the prevalence of HPV infection in pregnant women, to identify the types of the virus, and to evaluate the changes of prevalence of HPV infection depending on the trimester of pregnancy in Lithuania.
Two hundred and thirteen pregnant women who were attending centres of the central outpatient clinic of Vilnius city (Lithuania) in 2008-2010 were studied. These women were examined for HPV infection and its type by polymerase chain reaction. Tests were performed on the first and third trimesters. The statistical analysis was done using SPSS17 and Excel software.
At the beginning of the pregnancy (first trimester of pregnancy), HPV infection was detected in 17.8% of the pregnant women (38 from 213); high oncogenic risk HPV types were identified for 52.6% of the HPV-positive pregnant women. At the end of the pregnancy (third trimester of pregnancy), HPV was identified in 10.3% of the pregnant women (15 out of 146); high-risk HPV types were identified for 66.7%.
Our study shows the high prevalence of HPV infection in pregnant women in Lithuania. The majority of pregnant women's HPV infection was cleared during the pregnancy. Only in a few cases a new HPV infection was detected.
人乳头瘤病毒（HPV）是世界上最常见的性传播感染。据证实，大约 70%的性活跃人群都曾感染过这种病毒。孕妇 HPV 感染率为 5.5%至 65.0%。对孕妇 HPV 感染的研究结果并不一致，包括 HPV 感染率和 HPV 清除率。
我们旨在确定立陶宛孕妇 HPV 感染的流行率，确定病毒类型，并评估 HPV 感染的流行率根据孕期不同而变化。
2008 年至 2010 年，我们对 213 名在维尔纽斯市中央门诊中心就诊的孕妇进行了研究。这些妇女接受了聚合酶链反应（PCR）检测 HPV 感染及其类型。在第一和第三个三个月进行了测试。使用 SPSS17 和 Excel 软件进行统计分析。
在妊娠早期（妊娠第一个三个月），17.8%的孕妇（213 名孕妇中有 38 名）检测到 HPV 感染；HPV 阳性孕妇中 52.6%的 HPV 类型为高致癌风险。在妊娠晚期（妊娠第三个三个月），146 名孕妇中有 15 名（10.3%）检测到 HPV；高危 HPV 类型占 66.7%。
我们的研究表明立陶宛孕妇 HPV 感染率很高。大多数孕妇的 HPV 感染在怀孕期间得到清除。只有少数情况下会检测到新的 HPV 感染。
