Liu Yu, Zheng Dequan, Liu Xiaolin, Shi Xiaohong, Shu Shengchun, Li Jinbing
Department of Ultrasonography, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Andrology Center, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Front Pharmacol. 2019 Apr 4;10:312. doi: 10.3389/fphar.2019.00312. eCollection 2019.
To compare the sensitivity of identification of penile plaques in the erect and flaccid penises by ultrasound in patients with Peyronie's disease (PD).
A total of 75 PD patients were screened by palpation and ultrasonography for penile lesions in both flaccid and erect penises induced by prostaglandin E1 (PG-1) injection.
A total of 138 lesions were identified by ultrasound in the erect penises induced by injection of PG-1. However, only 74.6% of the lesions (103) were detectable by the palpation of the flaccid penises, and 84.1% (116) by ultrasound of the flaccid penises. The ultrasound confirmed 99 of the palpated lesions in the flaccid penises. The detection rate of lesions in drug-induced erect penises by ultrasound was significantly higher than those in the flaccid penises by the ultrasound ( < 0.01) or palpation ( < 0.0005) The type of penile lesions identified by ultrasonography included tunical thickening, calcifications, septal fibrosis, and intracavernosal fibrosis. The ratios of these lesions confirmed by ultrasound were 52.6, 33.6, 6.0, and 7.8%, respectively, in the flaccid penises, and 55.8, 28.3, 8.7, and 7.2%, respectively, in the erect penises.
Drug-induced erection can be used in suspicious PD patients when penile lesion is not identified by palpation or ultrasound in the flaccid penis.
比较超声检查在佩罗尼氏病（PD）患者勃起阴茎和疲软阴茎中识别阴茎硬结的敏感性。
对75例PD患者进行触诊和超声检查，以筛查由前列腺素E1（PG-1）注射诱发的疲软阴茎和勃起阴茎中的阴茎病变。
在PG-1注射诱发的勃起阴茎中，超声共识别出138处病变。然而，在疲软阴茎触诊中仅能检测到74.6%的病变（103处），在疲软阴茎超声检查中能检测到84.1%（116处）。超声证实了疲软阴茎触诊中的99处病变。超声检查在药物诱发的勃起阴茎中病变的检出率显著高于在疲软阴茎中的超声检查（<0.01）或触诊（<0.0005）。超声检查识别出的阴茎病变类型包括白膜增厚、钙化、中隔纤维化和海绵体内纤维化。这些病变在疲软阴茎中经超声证实的比例分别为52.6%、33.6%、6.0%和7.8%，在勃起阴茎中分别为55.8%、28.3%、8.7%和7.2%。
当在疲软阴茎中通过触诊或超声未发现阴茎病变时，药物诱发勃起可用于可疑的PD患者。
