Blackburn Brecken J, Jenkins Michael W, Rollins Andrew M, Dupps William J
Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States.
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Front Bioeng Biotechnol. 2019 Mar 29;7:66. doi: 10.3389/fbioe.2019.00066. eCollection 2019.
The study of corneal biomechanics is motivated by the tight relationship between biomechanical properties and visual function within the ocular system. For instance, variation in collagen fibril alignment and non-enzymatic crosslinks rank high among structural factors which give rise to the cornea's particular shape and ability to properly focus light. Gradation in these and other factors engender biomechanical changes which can be quantified by a wide variety of techniques. This review summarizes what is known about both the changes in corneal structure and associated changes in corneal biomechanical properties in aging, keratoconic, and photochemically crosslinked corneas. In addition, methods for measuring corneal biomechanics are discussed and the topics are related to both clinical studies and biomechanical modeling simulations.
角膜生物力学的研究源于眼内系统生物力学特性与视觉功能之间的紧密关系。例如，胶原纤维排列和非酶交联的变化在导致角膜特定形状和正确聚焦光线能力的结构因素中占比很高。这些因素以及其他因素的渐变会引发生物力学变化，而这些变化可以通过多种技术进行量化。本综述总结了关于衰老、圆锥角膜和光化学交联角膜中角膜结构变化以及相关角膜生物力学特性变化的已知信息。此外，还讨论了测量角膜生物力学的方法，并且这些主题与临床研究和生物力学建模模拟都相关。
