Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Department of Pathology and Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman, Jordan.
Biomed Res Int. 2019 Mar 25;2019:7087461. doi: 10.1155/2019/7087461. eCollection 2019.
Few reports of lupus nephritis (LN) from Jordan and the Middle East exist. This study assessed the demographic, clinical, and basic laboratory characteristics of Jordanian patients with LN and correlations with the histological class of LN.
This was a retrospective study of all patients who underwent kidney biopsy between 2007 and 2018 at a tertiary medical center in Jordan. Patients' demographic, clinical, laboratory, and pathological data were reviewed.
In total, 79 patients were included in this study [mean age, 29.95 ± 12.16 years; 11 men (13.9%), 68 women (86.1%)]. Asymptomatic proteinuria and hematuria were the most common presentations in LN patients at biopsy (59.5%). The study revealed a significant difference in frequency of nephritic syndrome (p= 0.01) between sexes (10.3% female vs. 45.5% male). Class IV was the most common pathological class of LN [37 (46.8%)], followed by class V [15 (19%)] and class III [10 (12.7%)]. Post hoc analysis of the associations between laboratory values and histopathological patterns revealed a significant correlation between class IV lupus and renal failure (p= 0.018) and class IV lupus and anti-DNA antibodies p= 0.030). End-stage renal disease (ESRD) occurred in 25% of lupus nephritis cases. There was an increased likelihood of ESRD among men than women (45% vs. 22%). Overall mortality was 10%.
Although some clinical and laboratory findings correlate with histological types of LN, clinical and laboratory parameters of Jordanian patients with LN are not predictive of the histological type, although differences with regional studies were noted.
来自约旦和中东地区的狼疮肾炎（LN）报告很少。本研究评估了约旦 LN 患者的人口统计学、临床和基本实验室特征，并与 LN 的组织学类型相关。
这是一项回顾性研究，纳入了 2007 年至 2018 年在约旦一家三级医疗中心接受肾活检的所有患者。回顾了患者的人口统计学、临床、实验室和病理数据。
本研究共纳入 79 例患者[平均年龄 29.95±12.16 岁；11 例男性（13.9%），68 例女性（86.1%）]。LN 患者在活检时最常见的表现为无症状蛋白尿和血尿（59.5%）。研究表明，男女之间肾病综合征的发生率存在显著差异（p=0.01）（女性 10.3%，男性 45.5%）。LN 最常见的组织学类型为 IV 型[37 例（46.8%）]，其次为 V 型[15 例（19%）]和 III 型[10 例（12.7%）]。实验室值与组织病理学模式之间的关联的事后分析显示，IV 型狼疮与肾衰竭之间存在显著相关性（p=0.018），IV 型狼疮与抗-DNA 抗体之间存在显著相关性（p=0.030）。终末期肾病（ESRD）在 25%的狼疮肾炎病例中发生。男性发生 ESRD 的可能性高于女性（45%比 22%）。总体死亡率为 10%。
尽管一些临床和实验室发现与 LN 的组织学类型相关，但约旦 LN 患者的临床和实验室参数不能预测组织学类型，尽管与区域研究存在差异。
