Diamineoxidase activity and tissue histamine content of human skin, breast and rectal carcinoma.

In view of the controversy that exists regarding the histamine content and diamine oxidase activity in relation to human carcinomatous growths, the present investigation was undertaken and carcinomatous tissues of skin, breast and rectum were analysed. The result of the experiment gives a clear evidence that both histamine concentration and diamine-oxidase activity increase significantly in all the three types of growth. The result has been discussed and a reasonable explanation has been offered for the observations made.