Marcus C S, Koyle M A, Darcourt J, Vivian M
Clin Nucl Med. 1986 Dec;11(12):834-9. doi: 10.1097/00003072-198612000-00007.
Twenty five In-111 oxine platelet imaging procedures were performed in 21 renal transplant patients to assess the value of this study for diagnosis of renal transplant rejection in recipients receiving cyclosporine (CYS) for immunosuppression. Fourteen biopsies were performed, and an extensive, in-depth review of the clinical progress of each patient was obtained. There was no ideal "gold standard" to which our imaging results could be compared, but we used a combination of biopsy findings, clinical impressions, and changes in renal function after pulsing with steroids and/or decreasing CYS dosage as the basis for our diagnoses. We were unable to distinguish between renal rejection and CYS toxicity using platelet imaging. The sensitivity of the platelet procedure for diagnosing rejection or CYS toxicity was 100%. The specificity for rejection or CYS toxicity was only 76.5%. In view of the inability of this test to distinguish between rejection and CYS toxicity, its rather low specificity, and its relatively high cost, it is not a particularly helpful study for the diagnosis of renal transplant rejection in patients on CYS.
对21例肾移植患者进行了25次铟-111氧喹啉血小板成像检查，以评估该研究对接受环孢素（CYS）免疫抑制的肾移植受者诊断肾移植排斥反应的价值。进行了14次活检，并对每位患者的临床进展进行了广泛、深入的回顾。没有理想的“金标准”可与我们的成像结果进行比较，但我们将活检结果、临床印象以及使用类固醇冲击和/或降低CYS剂量后肾功能的变化作为诊断依据。我们无法通过血小板成像区分肾排斥反应和CYS毒性。血小板检查诊断排斥反应或CYS毒性的敏感性为100%。诊断排斥反应或CYS毒性的特异性仅为76.5%。鉴于该检查无法区分排斥反应和CYS毒性，其特异性较低，且成本相对较高，因此对于接受CYS治疗的患者诊断肾移植排斥反应而言，它并不是一项特别有用的研究。
