Heyns A D, Lötter M G, Pieters H, Pauw F H, Badenhorst P N, Wessels P, Minnaar P C
Clin Nephrol. 1982 Oct;18(4):174-82.
Thirteen patients were investigated on 22 occasions at times varying from 1 day to 10 years after living family donor or cadaver renal transplantation. Platelet survival in the circulation, and in vivo platelet distribution and sites of deposition and sequestration was quantitatively determined with Indium-111-oxine (In-111-oxine) labelled platelets and a scintillation camera interfaced with a computer assisted imaging system. In all patients platelet survival was shortened and the platelet survival curve exponential. In patients with no evidence of transplant rejection and those with chronic rejection, there was no measurable or visible accumulation of labelled platelets in the kidney. The sequestration pattern of In-111 labelled platelets at the end of platelet life span was within normal limits and located in the reticuloendothelial system. In those patients with acute transplant rejection, platelet survival was shortened. Labelled platelets accumulated in the kidney: this was clearly visualized on scintigraphy and reflected by a significant increase in the radioactivity count density of the kidney. Platelets not deposited in the transplant were sequestrated in the reticuloendothelial system. This study demonstrates the diagnostic value of In-111 labelled platelet kinetics in the investigation of acute renal failure after renal transplantation. This investigation appears of limited clinical value in chronic rejection.
对13例患者进行了22次检查，检查时间为活体亲属供肾或尸体肾移植后1天至10年不等。采用铟-111-奥克辛（In-111-奥克辛）标记血小板和与计算机辅助成像系统相连的闪烁相机，定量测定循环中血小板的存活情况、体内血小板分布以及沉积和滞留部位。所有患者的血小板存活时间均缩短，且血小板存活曲线呈指数形式。在无移植排斥证据的患者和慢性排斥患者中，肾脏中未检测到或可见标记血小板的积聚。In-111标记血小板在血小板寿命末期的滞留模式在正常范围内，且位于网状内皮系统。在急性移植排斥患者中，血小板存活时间缩短。标记血小板在肾脏中积聚：这在闪烁扫描中清晰可见，并通过肾脏放射性计数密度的显著增加得以反映。未沉积在移植肾中的血小板在网状内皮系统中被滞留。本研究证明了In-111标记血小板动力学在肾移植后急性肾衰竭调查中的诊断价值。该调查在慢性排斥中似乎临床价值有限。
