Mortezaee Keywan, Ahmadi Amirhossein, Haghi-Aminjan Hamed, Khanlarkhani Neda, Salehi Ensieh, Shabani Nashtaei Maryam, Farhood Bagher, Najafi Masoud, Sahebkar Amirhossein
Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
J Cell Biochem. 2019 Aug;120(8):12101-12107. doi: 10.1002/jcb.28771. Epub 2019 Apr 25.
Chemotherapy, as a systemic therapy, is one of the most effective modalities for cancer treatment. However, the use of chemotherapeutic drugs in patients with breast cancer can lead to thyroid dysfunction. This systematic review summarizes the available data on thyroid function following breast cancer chemotherapy.
To illuminate the thyroid toxicities induced by different chemotherapy regimens in patients with breast cancer, a systematic search was done in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline in Scopus, Embase, PubMed and Web of Science electronic databases up to December 2018. On the basis of a set of prespecified inclusion and exclusion criteria, eight eligible articles providing data on thyroid function following chemotherapy in patients with breast cancer were included in the study.
According to the obtained results, it was found that for most cases, the levels of triiodothyronine (T3), free T3 (FT3), thyroxin (T4) and free T4 (FT4) hormones decrease following breast cancer chemotherapy regimens used in these eligible studies. However, alteration of thyroid-stimulating hormone (TSH) level after breast cancer chemotherapy was not clear.
The findings showed that thyroid function and TSH hormone level can change in patients with breast cancer receiving different chemotherapy regimens.
化疗作为一种全身治疗方法，是癌症治疗最有效的方式之一。然而，乳腺癌患者使用化疗药物会导致甲状腺功能障碍。本系统综述总结了乳腺癌化疗后甲状腺功能的现有数据。
为阐明不同化疗方案对乳腺癌患者甲状腺的毒性作用，根据系统评价与Meta分析的首选报告项目指南，于2018年12月前在Scopus、Embase、PubMed和Web of Science电子数据库中进行了系统检索。根据一组预先设定的纳入和排除标准，本研究纳入了8篇提供乳腺癌患者化疗后甲状腺功能数据的合格文章。
根据所得结果发现，在这些合格研究中使用的乳腺癌化疗方案后，大多数情况下，三碘甲状腺原氨酸（T3）、游离T3（FT3）、甲状腺素（T4）和游离T4（FT4）激素水平会降低。然而，乳腺癌化疗后促甲状腺激素（TSH）水平的变化并不明确。
研究结果表明，接受不同化疗方案的乳腺癌患者的甲状腺功能和TSH激素水平会发生变化。
