[Cytotoxic factors of neutrophils in rats with 7,12-dimethylbenz[a]anthracene-induced sarcoma].

A study of intraleukocyte cytotoxic system and phagocytic function of granulocytes was carried out in rats with 7,12-dimethylbenz(a)anthracene-induced sarcoma. There were no distinctive alterations of microbicidal factors of polymorphonuclear neutrophils (PMN) at the initial stage of the tumour growth. The inhibition of some antibiotic neutrophil factors at later stages of the tumour growth in rats was compensated by preferential activity of others. The essential impairments of both the oxygen-dependent and oxygen-independent mechanism of cytotoxicity of PMN at the terminal stage of sarcoma growth were detected. At the same time the phagocytic activity of neutrophils was depressed.