Shurin M R, Kusnecov A, Hamill E, Kaplan S, Rabin B S
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15213-2582.
Brain Behav Immun. 1994 Jun;8(2):163-9. doi: 10.1006/brbi.1994.1015.
We have used a laboratory model of footshock stress in rats to determine whether stressor-induced alterations can be induced in polymorphonuclear leukocyte (PMN) function. We studied the ability of peripheral blood PMN to ingest and kill gram-positive bacteria. A single, 1-h session of footshock stress did not alter the ability of PMN to ingest or kill bacteria. However, 3 consecutive days of a 1-h session of footshock stress significantly enhanced the phagocytic activity of PMN but suppressed the ability of PMN to kill bacteria. Thus, this experimental model suggests that both the phagocytic and killing functions of PMN can be altered by repeated exposure to a stressor.
我们使用大鼠足部电击应激的实验室模型来确定应激源诱导的改变是否能在多形核白细胞（PMN）功能中诱发。我们研究了外周血PMN摄取和杀灭革兰氏阳性菌的能力。单次1小时的足部电击应激并未改变PMN摄取或杀灭细菌的能力。然而，连续3天每天1小时的足部电击应激显著增强了PMN的吞噬活性，但抑制了PMN杀灭细菌的能力。因此，该实验模型表明，重复暴露于应激源可改变PMN的吞噬和杀伤功能。
