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The determination of 7-chloro-1,3-dihydro-5-(2',chlorophenyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3027) and its metabolite (lorazepam) in blood and urine by electron-capture gas liquid chromatography.

作者信息

de Silva J A, Bekersky I, Puglisi C V

出版信息

J Chromatogr Sci. 1973 Oct;11(10):547-52. doi: 10.1093/chromsci/11.10.547.

DOI:10.1093/chromsci/11.10.547
PMID:4750858
Abstract
摘要

相似文献

1
The determination of 7-chloro-1,3-dihydro-5-(2',chlorophenyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3027) and its metabolite (lorazepam) in blood and urine by electron-capture gas liquid chromatography.
J Chromatogr Sci. 1973 Oct;11(10):547-52. doi: 10.1093/chromsci/11.10.547.
2
Determination of 7-iodo-1,3-dihydro-1-methyl-5(2'-fluorophenyl)-2h-1,4-benzodiazepin-2-one (Ro 7-9957) and its major biotransformation products in blood and urine by electron capture-gas-liquid chromatography.
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3
Determination of clonazepam and flunitrazepam in blood and urine by electron-capture GLC.
J Pharm Sci. 1974 Apr;63(4):520-7. doi: 10.1002/jps.2600630406.
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Determination of 7-bromo-1,3-dihydro-5(2-pyridyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3350) in blood by gas-liquid chromatography.气液色谱法测定血液中7-溴-1,3-二氢-5(2-吡啶基)-2H-1,4-苯并二氮杂卓-2-酮（Ro 5-3350）
J Pharm Sci. 1966 Nov;55(11):1278-83. doi: 10.1002/jps.2600551122.
5
Identification of flurazepam (Dalmane) and a primary metabolite in urine by thin-layer chromatography.
J Forensic Sci. 1975 Jan;20(1):38-44.
6
Disposition of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in humans. Determination of the drug by electron capture gas chromatography.7-氯-5-（邻氯苯基）-1,3-二氢-3-羟基-2H-1,4-苯并二氮杂卓-2-酮（劳拉西泮）在人体内的处置。通过电子捕获气相色谱法测定该药物。
Arzneimittelforschung. 1971 Jul;21(7):1055-9.
7
GLC-ECD determination of 1-(2-hydroxyethyl)-3-hydroxy-7-chloro-1,3-dihydro-5-(O-fluorophenyl)-2H-1,4-benzodiazepin-2-one (SAS 643) in plasma and urine and identification of its main biotransformation products.
Ther Drug Monit. 1981;3(4):351-6. doi: 10.1097/00007691-198104000-00005.
8
Double-blind cross-over clinical comparison of two 2'-chloro benzodiazepines: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam) versus 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam) in neurotic anxiety.两种2'-氯苯二氮䓬类药物的双盲交叉临床比较：7-氯-5-(2-氯苯基)-1,3-二氢-2H-1,4-苯并二氮杂䓬-2-酮（去甲氯氮卓）与7-氯-5-(邻氯苯基)-1,3-二氢-3-羟基-2H-1,4-苯并二氮杂䓬-2-酮（劳拉西泮）治疗神经症性焦虑的比较
Arzneimittelforschung. 1977 Feb;27(2):436-9.
9
7-Bromo-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (I), a new tranquillizing agent: metabolism in rats.
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10
Electron-capture GLC determination of blood levels of 7-chloro-1,3-dihydro-5-(2'-chlorophenyl)-2H-1,4-benzodiazepin-2-one in humans and its urinary excretion as lorazepam determined by differential pulse polarography.
J Pharm Sci. 1974 Dec;63(12):1943-5. doi: 10.1002/jps.2600631226.

引用本文的文献

1
Biotransformation and excretion of lorazepam in patients with chronic renal failure.慢性肾衰竭患者中劳拉西泮的生物转化和排泄。
Br J Clin Pharmacol. 1976 Dec;3(6):1033-9. doi: 10.1111/j.1365-2125.1976.tb00354.x.
2
Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans.去甲氯氮卓单次口服给药在人体内的药代动力学。
Eur J Drug Metab Pharmacokinet. 1986 Jul-Sep;11(3):171-4. doi: 10.1007/BF03189844.
3
Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans.
氯地西泮静脉注射和口服给药在人体中的药代动力学及生物利用度
Eur J Clin Pharmacol. 1988;34(1):109-12. doi: 10.1007/BF01061430.
4
Effect of a cocktail on diazepam absorption.鸡尾酒对安定吸收的影响。
Psychopharmacology (Berl). 1978 Apr 28;57(2):199-203. doi: 10.1007/BF00426888.