Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, PR China; Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, PR China; Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
J Mech Behav Biomed Mater. 2019 Jul;95:220-231. doi: 10.1016/j.jmbbm.2019.04.029. Epub 2019 Apr 17.
The influence of Mg content on the mechanical properties, degradation behavior, in vitro cell adhesion, and in vivo behavior of as-extruded Zn-xMg-0.1Ca (x = 0.5 wt%, 1.0 wt%, 1.5 wt%) alloys was investigated. A high Mg content could increase the volume fraction of the hard MgZn phase distributed at grain boundaries. This condition could significantly improve yield strength and ultimate tensile strength. Mg addition could adjust the degradation rate of Zn alloys and influence cytocompatibility. ZnMg1Ca0.1 alloy showed the highest adhesion density of bone marrow-derived mesenchymal stem cells (BMSCs) because the degradation rate of ZnMg1Ca0.1 alloy could supply appropriate pH and [Zn] for BMSCs. Mg addition could improve the cytocompatibility of ZnMgCa alloys. However, a Mg content threshold was observed, and the Mg content should be exactly controlled. Combined with the mechanical properties, the degradation rate of zinc alloy implants could be adjusted to match the healing of tissues by adding Mg. In vivo results showed that the degradation rate of the optimized ZnMgCa alloy could match the healing of local tissues or organs. Animal implant results revealed alloy safety.
研究了镁含量对挤压态 Zn-xMg-0.1Ca（x=0.5wt%、1.0wt%、1.5wt%）合金的力学性能、降解行为、体外细胞黏附性和体内行为的影响。高镁含量可以增加分布在晶界处的硬 MgZn 相的体积分数。这种情况可以显著提高屈服强度和极限拉伸强度。镁的添加可以调整锌合金的降解速率并影响细胞相容性。ZnMg1Ca0.1 合金表现出最高的骨髓间充质干细胞（BMSCs）黏附密度，因为 ZnMg1Ca0.1 合金的降解速率可以为 BMSCs 提供合适的 pH 值和[Zn]。镁的添加可以提高 ZnMgCa 合金的细胞相容性。然而，观察到镁含量的阈值，并且应该精确控制镁含量。结合力学性能，通过添加镁可以调整锌合金植入物的降解速率以匹配组织的愈合。体内结果表明，优化的 ZnMgCa 合金的降解速率可以与局部组织或器官的愈合相匹配。动物植入物结果显示了合金的安全性。
