School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.
National Demonstration Center for Experimental Function Materials Education, Tianjin University of Technology, Tianjin 300384, China.
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110397. doi: 10.1016/j.msec.2019.110397. Epub 2019 Nov 5.
Zinc has attracted increasing attention in the field of degradable implant materials due to its suitable degradation rate. To further improve the mechanical properties and biocompatibility of zinc, Zn-1Mg-nvol%β-TCP (n = 0, 1, 3, 5) composites were fabricated for biomedical application by the mechanical stirring combined with ultrasonic assisted casting and hot extrusion technology. The microstructure, mechanical properties and corrosion behavior of these composites were systemically investigated and the composite with the best comprehensive performance were selected for biocompatibility evaluation including L-929 cells cytotoxicity test and SD rat model experiment. Tensile test revealed that Zn-1Mg-1vol%β-TCP composite possessed optimal mechanical properties. The yield strength (YS), ultimate tensile strength (UTS), elongation (σ) and elastic modulus (E) of the as-extruded Zn-1Mg-1vol%β-TCP composite are 250.8 MPa, 330.5 MPa, 11.7% and 125.4 GPa respectively. The immersion tests showed that the corrosion resistance of the composite is slightly decreased with the increase of β-TCP content. In addition, the addition of β-TCP makes the cytocompatibility of the composites better than that of the Zn-1Mg alloy matrix. Various blood biochemical parameters in rat serum samples after implantation showed Zn-1Mg alloy and Zn-1Mg-β-TCP composites has not significant tissue inflammation and showed good biocompatibility.
锌因其适宜的降解速率而在可降解植入材料领域引起了越来越多的关注。为了进一步提高锌的机械性能和生物相容性，采用机械搅拌结合超声辅助铸造和热挤压技术，制备了用于生物医学应用的 Zn-1Mg-nvol%β-TCP(n=0,1,3,5)复合材料。系统研究了这些复合材料的微观结构、力学性能和腐蚀行为，并选择综合性能最佳的复合材料进行生物相容性评价，包括 L-929 细胞细胞毒性试验和 SD 大鼠模型试验。拉伸试验表明，Zn-1Mg-1vol%β-TCP 复合材料具有最佳的力学性能。挤压态 Zn-1Mg-1vol%β-TCP 复合材料的屈服强度(YS)、抗拉强度(UTS)、伸长率(σ)和弹性模量(E)分别为 250.8 MPa、330.5 MPa、11.7%和 125.4 GPa。浸泡试验表明，复合材料的耐腐蚀性随β-TCP 含量的增加而略有降低。此外，β-TCP 的添加使复合材料的细胞相容性优于 Zn-1Mg 合金基体。植入后大鼠血清样本中的各种血液生化参数表明，Zn-1Mg 合金和 Zn-1Mg-β-TCP 复合材料无明显组织炎症，具有良好的生物相容性。
