Fillo J, Levcikova M, Luha J, Ondrus D
Bratisl Lek Listy. 2019;120(4):291-294. doi: 10.4149/BLL_2019_039.
Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing.
Totally, 45 males with testosterone deficiency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used.
Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a significant improvement (p < 0.001).
Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18).
文献中仍缺少睾酮替代疗法（TRT）对骨矿物质密度（BMD）的长期影响结果。
共有45例睾酮缺乏综合征（TDS）男性接受了TRT治疗。平均年龄为57.84岁，随访期为94.62个月。男性接受每三个月一次、每次1000毫克十一酸睾酮的肌肉注射治疗。在治疗开始时、两年后和五年后检查骨密度。进行统计学评估时，使用非参数威尔科克森检验。
腰椎的平均骨密度在开始时为1.067，两年后为1.122，五年后为1.667。两年后和五年后的结果均显示出显著改善（p < 0.001）。
作者证明了长期TRT对腰椎骨密度有积极影响。全髋部骨密度测量也显示有改善，但仅在五年后。股骨颈骨密度相对稳定。重要的是，尽管男性年龄增长，但腰椎的骨密度值仍有所改善（图6，参考文献18）。
