Basurto Lourdes, Zarate Arturo, Gomez Raquel, Vargas Columba, Saucedo Renata, Galván Rosa
Department of Internal Medicine, Endocrine Research Unit and Department of Radiology, National Medical Center, Mexico City, Mexico.
Aging Male. 2008 Sep;11(3):140-5. doi: 10.1080/13685530802273715.
The aim of the present study was to analyse the effect of testosterone therapy on bone mineral density in healthy elderly men who had low levels of total testosterone.
Randomized, double-blind, placebo-controlled study.
Forty-eight men over 60 years old with decreased testosterone levels (< or =320 ng/dL) comprised the study. Twenty-five out of 48 received intramuscular injections of testosterone enanthate every three weeks during 12 months; the remaining 23 participants formed the control group. All participants had measurements of bone mineral density (BMD) in both lumbar spine and hip before and at the end of the study as well as testosterone and 17-beta estradiol levels.
Testosterone treated group exhibited a significant (p < 0.05) increment (from 1.198 +/- 0.153 to 1.240 +/- 0.141 g/cm(2)) in lumbar BMD in parallel with a significant (p < 0.001) increment (from 301 +/- 32 to 471 +/- 107 ng/dL) in testosterone concentrations, whereas no significant change occurred in femoral neck BMD.
Testosterone therapy elicited a positive effect only in lumbar BMD in elderly men with diminished testosterone serum levels.
本研究旨在分析睾酮治疗对总睾酮水平较低的健康老年男性骨矿物质密度的影响。
随机、双盲、安慰剂对照研究。
48名60岁以上睾酮水平降低（≤320 ng/dL）的男性组成了该研究。48名参与者中有25名在12个月内每三周接受一次庚酸睾酮的肌肉注射；其余23名参与者组成对照组。所有参与者在研究开始前和结束时均测量了腰椎和髋部的骨矿物质密度（BMD）以及睾酮和17-β雌二醇水平。
睾酮治疗组腰椎骨密度显著增加（p < 0.05）（从1.198 ± 0.153增加到1.240 ± 0.141 g/cm²），同时睾酮浓度显著增加（p < 0.001）（从301 ± 32增加到471 ± 107 ng/dL），而股骨颈骨密度没有显著变化。
睾酮治疗仅对血清睾酮水平降低的老年男性的腰椎骨密度产生了积极影响。
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