Fillo J, Breza J, Ondrusova M, Luha J, Ondrus D, Dubravicky J, Breza J, Labas P, Levcikova M
Bratisl Lek Listy. 2018;119(9):577-580. doi: 10.4149/BLL_2018_061.
In this article, the authors evaluate subjective and objective results of long testosterone replacement therapy (TRT) and possible risk.
In a single center study, the authors treated 69 men with testosterone deficiency syndrome (TDS). The average age was 57.84 years and the follow-up period was 94.62 months. All men had at beginning a complete urological and internal examination. All the men were treated with three-month i.m. injections of 1000 mg testosterone undecanoate. The men were regularly checked according to the EAU guidelines.
All of the men on treatment felt much better. Weight and waist circumference during monitoring showed a mild improvement. Excellent results were on red blood cells. Glucose, HDL cholesterol, triglycerides had stable values. PSA slightly increased and testosterone was within the normal range. In two men during treatment, we found a prostate cancer (low risk). Bone mineral density (BMD) of lumbar spine revealed a significant improvement.
TRT had multiple positive effect on affected men with TDS. Our long-term results showed a long mild improvement during the time. Authors concluded that long term treatment had multiple benefit for affected men (Fig. 11, Ref. 13).
在本文中，作者评估了长期睾酮替代疗法（TRT）的主观和客观结果以及可能存在的风险。
在一项单中心研究中，作者对69名患有睾酮缺乏综合征（TDS）的男性进行了治疗。平均年龄为57.84岁，随访期为94.62个月。所有男性在开始时均进行了全面的泌尿外科和内科检查。所有男性均接受每三个月一次、每次1000毫克十一酸睾酮的肌肉注射治疗。这些男性按照欧洲泌尿外科学会（EAU）指南定期接受检查。
所有接受治疗的男性感觉好多了。监测期间的体重和腰围有轻微改善。红细胞方面取得了优异结果。血糖、高密度脂蛋白胆固醇、甘油三酯的值保持稳定。前列腺特异性抗原（PSA）略有升高，睾酮处于正常范围内。在两名接受治疗的男性中，我们发现了前列腺癌（低风险）。腰椎骨密度（BMD）有显著改善。
TRT对患有TDS的男性有多种积极影响。我们的长期结果显示，在此期间有长期的轻微改善。作者得出结论，长期治疗对受影响的男性有多种益处（图11，参考文献13）。
