Department of Bioengineering, University of Washington, 355061, 3720 15th Ave NE, Seattle WA 98195, United States.
Department of Bioengineering, University of Washington, 355061, 3720 15th Ave NE, Seattle WA 98195, United States.
Med Eng Phys. 2019 Jun;68:101-107. doi: 10.1016/j.medengphy.2019.04.002. Epub 2019 Apr 22.
People with transtibial limb loss experience daily changes in volume of their residual limb that affect the fit of their prosthetic socket. A portable instrument was developed to monitor fluid volume changes outside of the laboratory setting. The bioimpedance system applied 26 current bursts per second at frequencies between 3 kHz and 1 MHz, and sensed voltage at up to six channels. Among six voltage-controlled current source circuits and five receive-channel amplifier topologies considered, a differential Howland current pump and a single receive-channel instrumentation amplifier proved the best combination of low noise and low power consumption. Mean RMS errors were 0.07% for extracellular fluid resistance, 2.23% for intracellular fluid resistance, and 1.15% for membrane capacitance.
小腿截肢者的残肢每天都会经历体积变化,这会影响假肢接受腔的适配。一种便携式仪器被开发出来,用于在实验室环境之外监测液体体积变化。该生物阻抗系统以每秒 26 个电流脉冲的频率在 3 kHz 到 1 MHz 之间施加电流,并在多达六个通道上感测电压。在所考虑的六个电压控制电流源电路和五个接收通道放大器拓扑结构中,差分 Howland 电流泵和单个接收通道仪表放大器被证明是低噪声和低功耗的最佳组合。细胞外液电阻的平均 RMS 误差为 0.07%,细胞内液电阻的平均 RMS 误差为 2.23%,膜电容的平均 RMS 误差为 1.15%。