Tanphaichitra D, Sahaphong S, Srimuang S
Infection. 1986;14 Suppl 4:S321-3. doi: 10.1007/BF01661308.
During 1984 to 1986, 121 patients with gonorrhoea were treated with ofloxacin. This report is to summarize the results of our trial in patients treated with three different dose regimens of ofloxacin: A) a single 800 mg dose of ofloxacin (32 patients); B) a single 400 mg dose of ofloxacin (55 patients) or C) a twice a day dose of 600 mg ofloxacin (34 patients). In addition, 19 patients with urinary tract infection and eight patients with enteric fever were treated with 400 mg ofloxacin twice a day for seven to ten days. Out of 121 patients with gonococcal urethritis, only 107 patients were evaluable. Cure was obtained in 96.5%; 93.2% and 94.5% of the patients in groups A, B and C respectively. 16 out of 17 patients with urinary tract infection achieved clinical cure or improvement. The 16 patients were bacteriologically accessible; pathogens were eradicated in all of them. Ofloxacin was also effective in the treatment of enteric fever, in which eradication was achieved in all seven patients. 28% of Neisseria gonorrhoea and 29% of Salmonella spp. isolated in our community were beta-lactamase-positive.
1984年至1986年期间，121例淋病患者接受了氧氟沙星治疗。本报告旨在总结我们对使用三种不同剂量方案的氧氟沙星治疗患者的试验结果：A）单次服用800毫克氧氟沙星（32例患者）；B）单次服用400毫克氧氟沙星（55例患者）或C）每天两次服用600毫克氧氟沙星（34例患者）。此外，19例尿路感染患者和8例肠热症患者接受了每天两次400毫克氧氟沙星治疗，疗程为7至10天。在121例淋菌性尿道炎患者中，只有107例患者可进行评估。A、B、C组分别有96.5%、93.2%和94.5%的患者治愈。17例尿路感染患者中有16例实现了临床治愈或病情改善。这16例患者可进行细菌学检测；所有患者的病原体均被根除。氧氟沙星对肠热症也有效，7例患者全部实现了病原体根除。在我们社区分离出的淋病奈瑟菌中有28%和沙门氏菌属中有29%是β-内酰胺酶阳性。
