Prakash Chandra, Sachdev Suchet, Marwaha Neelam, Hans Rekha
M.Sc. Medical Technology (Transfusion Medicine), Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Assistant Professor, Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Clin Exp Hepatol. 2019 Mar-Apr;9(2):156-161. doi: 10.1016/j.jceh.2018.03.001. Epub 2018 Apr 5.
The aim of the present study was to know the prevalence of viral hepatitis markers among blood donors deferred on the basis of a history of jaundice of unknown origin and to predict the impact of this deferral on blood safety.
Observational study included 200 blood donors deferred on the basis of a history of jaundice of unknown origin and carried out serology and Individual Donation Nucleic Acid Testing (ID-NAT) for hepatitis B and hepatitis C.
Five (2.5%) out of 200 blood donors deferred on the basis of history of jaundice were reactive on ELISA. Three out of five were reactive for HBsAg; whereas two for anti-HCV antibodies. Out of the 12 ID-NAT initial reactive, 10 samples discriminated on further testing; 4 for HBV, 5 for HCV and 1 was co-infection (HBV + HCV). The odds of being picked up as sero reactive on ELISA was 2.53 (95% CI; 1.04-6.19) and being picked up as ID-NAT yield was 13.08 (95% CI; 5.29-32.37) in donors deferred on a history of jaundice of unknown origin as compared to selected donors without a history of jaundice, with the difference in means achieving statistically significance at = 0.03 and <0.001 respectively.The potential of deferral on a history of jaundice of unknown origin has a capacity to interdict 2-3 HBV and/or HCV reactive blood donors on serology and 5 HBV and/or HCV reactive blood donors on ID-NAT from entering the quarantine blood supply per 100 donors.
The findings of the present study support that a deferral for a history of jaundice of unknown origin after attaining the age of 12 years in the present scenario of transfusion transmissible infectious disease screening in India.
本研究旨在了解因不明原因黄疸病史而被延期献血者中病毒性肝炎标志物的流行情况，并预测这种延期对血液安全的影响。
观察性研究纳入了200名因不明原因黄疸病史而被延期献血的献血者，并对其进行了乙肝和丙肝的血清学检测及个体献血核酸检测（ID-NAT）。
在因黄疸病史而被延期的200名献血者中，有5名（2.5%）ELISA检测呈阳性。5名中有3名HBsAg呈阳性；2名抗-HCV抗体呈阳性。在12名ID-NAT初筛呈阳性的样本中，有10个样本在进一步检测后得以区分；4个为乙肝，5个为丙肝，1个为合并感染（乙肝+丙肝）。与无黄疸病史的选定献血者相比，因不明原因黄疸病史而被延期的献血者在ELISA检测中呈血清学阳性的几率为2.53（95%CI：1.04-6.19），在ID-NAT检测中呈阳性的几率为13.08（95%CI：5.29-32.37），均值差异分别在α=0.03和<0.001时具有统计学意义。因不明原因黄疸病史而延期献血有能力在血清学检测中阻断每100名献血者中有2-3名乙肝和/或丙肝血清学阳性的献血者进入检疫血液供应，在ID-NAT检测中阻断5名乙肝和/或丙肝血清学阳性的献血者。
本研究结果支持在印度目前的输血传播感染性疾病筛查情况下，12岁以后因不明原因黄疸病史而延期献血。
