Siddique Rabeea, Liu Yang, Nabi Ghulam, Sajjad Wasim, Xue Mengzhou, Khan Suliman
Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou University, Zhengzhou, China.
The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Neurol. 2019 Apr 9;10:319. doi: 10.3389/fneur.2019.00319. eCollection 2019.
Since the beginning of the Zika Virus (ZIKV) epidemic, thousands of cases presenting ZIKV symptoms were recorded in Brazil, Colombia (South America), French Polynesia and other countries of Central and North America. In Brazil, during ZIKV outbreak thousands of microcephaly cases occurred that caused a state of urgency among scientists and researchers to confirm the suspected association between ZIKV infection and microcephaly. In this review article we comprehensively studied scientific literature to analyze ZIKV relationship with microcephaly, recent experimental studies, challenge and shortcomings in previously published reports to know about the current status of this association. The evidences supporting the association of ZIKV infection with congenital microcephaly and fetal brain tissue damage is rapidly increasing, and supplying recent information about pathology, clinical medicine, epidemiology, mechanism and experimental studies. However, serious attention is required toward ZIKV vaccine development, standardization of anthropometric techniques, centralization of data, and advance research to clearly understand the mechanism of ZIKV infection causing microcephaly.
自寨卡病毒（ZIKV）疫情爆发以来，巴西、哥伦比亚（南美洲）、法属波利尼西亚以及中美洲和北美洲的其他国家记录了数千例出现寨卡病毒症状的病例。在巴西，寨卡病毒爆发期间出现了数千例小头畸形病例，这使得科学家和研究人员迫切需要确认寨卡病毒感染与小头畸形之间的疑似关联。在这篇综述文章中，我们全面研究了科学文献，以分析寨卡病毒与小头畸形的关系、近期的实验研究、先前发表报告中的挑战和不足，从而了解这种关联的现状。支持寨卡病毒感染与先天性小头畸形及胎儿脑组织损伤之间存在关联的证据正在迅速增加，并提供了有关病理学、临床医学、流行病学、机制和实验研究的最新信息。然而，在寨卡病毒疫苗研发、人体测量技术标准化、数据集中化以及深入研究以清楚了解寨卡病毒感染导致小头畸形的机制方面，仍需要给予高度关注。
