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大肠杆菌素和沙门菌素——新型植物源非抗生素食品抗菌剂。

Colicins and Salmocins - New Classes of Plant-Made Non-antibiotic Food Antibacterials.

作者信息

Hahn-Löbmann Simone, Stephan Anett, Schulz Steve, Schneider Tobias, Shaverskyi Anton, Tusé Daniel, Giritch Anatoli, Gleba Yuri

机构信息

NOMAD Bioscience GmbH, Halle, Germany.

DT/Consulting Group, Sacramento, CA, United States.

出版信息

Front Plant Sci. 2019 Apr 9;10:437. doi: 10.3389/fpls.2019.00437. eCollection 2019.

DOI:10.3389/fpls.2019.00437
PMID:31024601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6465592/
Abstract

Recently, several plant-made recombinant proteins received favorable regulatory review as food antibacterials in the United States through the Generally Recognized As Safe (GRAS) regulatory procedure, and applications for others are pending. These food antimicrobials, along with approved biopharmaceuticals and vaccines, represent new classes of products manufactured in green plants as production hosts. We present results of new research and development and summarize regulatory, economic and business aspects of the antibacterial proteins colicins and salmocins as new food processing aids.

摘要

最近，几种植物源重组蛋白通过“一般认为安全”（GRAS）监管程序在美国作为食品抗菌剂获得了有利的监管审查，其他一些产品的申请正在审批中。这些食品抗菌剂，连同已获批的生物制药和疫苗，代表了以绿色植物作为生产宿主制造的新型产品类别。我们展示了新的研发成果，并总结了作为新型食品加工助剂的大肠杆菌素和沙门菌素等抗菌蛋白在监管、经济和商业方面的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/d757847f8c12/fpls-10-00437-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/0c0fa7736173/fpls-10-00437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/74f57fcf8253/fpls-10-00437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/6c10f36db582/fpls-10-00437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/7046429096b0/fpls-10-00437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/1273045496e8/fpls-10-00437-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/387563ebb420/fpls-10-00437-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/dc1ec34e0bb8/fpls-10-00437-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/ddfa4d723897/fpls-10-00437-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/d757847f8c12/fpls-10-00437-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/0c0fa7736173/fpls-10-00437-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/74f57fcf8253/fpls-10-00437-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/6c10f36db582/fpls-10-00437-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/7046429096b0/fpls-10-00437-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/1273045496e8/fpls-10-00437-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/387563ebb420/fpls-10-00437-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/dc1ec34e0bb8/fpls-10-00437-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/ddfa4d723897/fpls-10-00437-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6a0/6465592/d757847f8c12/fpls-10-00437-g009.jpg

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