• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

前瞻性随机On-X瓣膜抗凝临床试验（PROACT）：越低越好，但这足够好吗？

The Prospective Randomized On-X Valve Anticoagulation Clinical Trial (PROACT): Lower is better, but is it good enough?

作者信息

Bouhout Ismail, El-Hamamsy Ismail

机构信息

Department of Cardiac Surgery, Montreal Heart Institute, Université de Montreal, Quebec, Canada.

出版信息

Glob Cardiol Sci Pract. 2019 Mar 31;2019(1):2. doi: 10.21542/gcsp.2019.2.

DOI:10.21542/gcsp.2019.2
PMID:31024944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472691/
Abstract

Due to their durability, mechanical prostheses are frequently used for aortic valve replacement (AVR) in young adults. However, these valves are thrombogenic and require lifelong anticoagulation. Over the last few decades, efforts have been made towards the lowering of INR targets in an effort to reduce bleeding events without influencing the thromboembolic risk. The Prospective Randomized On-X Valve Anticoagulation Clinical Trial (PROACT) was designed to compare standard versus low anticoagulation targets in high-risk patients undergoing mechanical AVR with the ON-X prosthesis.

摘要

由于其耐用性，机械瓣膜常用于年轻成人的主动脉瓣置换术（AVR）。然而，这些瓣膜具有血栓形成性，需要终身抗凝。在过去几十年中，人们努力降低国际标准化比值（INR）目标，以减少出血事件，同时不影响血栓栓塞风险。前瞻性随机On-X瓣膜抗凝临床试验（PROACT）旨在比较接受On-X机械瓣膜置换术的高危患者的标准抗凝目标与低抗凝目标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/b9197d1bb3d5/gcsp-2019-1-e201902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/b96c7a43d851/gcsp-2019-1-e201902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/29c4b9e55cca/gcsp-2019-1-e201902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/21fa37f45017/gcsp-2019-1-e201902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/b9197d1bb3d5/gcsp-2019-1-e201902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/b96c7a43d851/gcsp-2019-1-e201902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/29c4b9e55cca/gcsp-2019-1-e201902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/21fa37f45017/gcsp-2019-1-e201902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa52/6472691/b9197d1bb3d5/gcsp-2019-1-e201902-g004.jpg

相似文献

1
The Prospective Randomized On-X Valve Anticoagulation Clinical Trial (PROACT): Lower is better, but is it good enough?前瞻性随机On-X瓣膜抗凝临床试验（PROACT）：越低越好，但这足够好吗？
Glob Cardiol Sci Pract. 2019 Mar 31;2019(1):2. doi: 10.21542/gcsp.2019.2.
2
Reduced anticoagulation is safe in high-risk patients with the On-X mechanical aortic valve.对于植入On-X机械主动脉瓣的高危患者，减少抗凝治疗是安全的。
Curr Opin Cardiol. 2015 Mar;30(2):140-145. doi: 10.1097/HCO.0000000000000149.
3
LOWERing the INtensity of oral anticoaGulant Therapy in patients with bileaflet mechanical aortic valve replacement: results from the "LOWERING-IT" Trial.降低二叶式机械主动脉瓣置换术后患者口服抗凝强度：“LOWERING-IT”试验结果。
Am Heart J. 2010 Jul;160(1):171-8. doi: 10.1016/j.ahj.2010.05.005.
4
Reduced anticoagulation after mechanical aortic valve replacement: interim results from the prospective randomized on-X valve anticoagulation clinical trial randomized Food and Drug Administration investigational device exemption trial.机械主动脉瓣置换术后的抗凝治疗降低：前瞻性随机 ON-X 瓣膜抗凝临床试验随机食品和药物管理局研究性器械豁免试验的中期结果。
J Thorac Cardiovasc Surg. 2014 Apr;147(4):1202-1210; discussion 1210-1. doi: 10.1016/j.jtcvs.2014.01.004. Epub 2014 Jan 12.
5
Anticoagulation and Antiplatelet Strategies After On-X Mechanical Aortic Valve Replacement.On-X 机械主动脉瓣置换术后的抗凝和抗血小板策略。
J Am Coll Cardiol. 2018 Jun 19;71(24):2717-2726. doi: 10.1016/j.jacc.2018.03.535.
6
Low target-INR anticoagulation is safe in selected aortic valve patients with the Medtronic Open Pivot mechanical prosthesis: long-term results of a propensity-matched comparison with standard anticoagulation.对于使用美敦力开放式枢轴机械瓣膜的特定主动脉瓣患者，低目标国际标准化比值（INR）抗凝治疗是安全的：与标准抗凝治疗倾向匹配比较的长期结果
Interact Cardiovasc Thorac Surg. 2017 Jun 1;24(6):862-868. doi: 10.1093/icvts/ivx028.
7
Prosthetic valve type for patients undergoing aortic valve replacement: a decision analysis.接受主动脉瓣置换术患者的人工瓣膜类型：一项决策分析
Ann Thorac Surg. 2000 Dec;70(6):1946-52. doi: 10.1016/s0003-4975(00)01863-4.
8
Thromboembolic and bleeding complications following St. Jude Medical valve replacement: results of the German Experience With Low-Intensity Anticoagulation Study.圣犹达医疗瓣膜置换术后的血栓栓塞和出血并发症：德国低强度抗凝治疗研究的结果
Chest. 2005 Jan;127(1):53-9. doi: 10.1378/chest.127.1.53.
9
INR self-management permits lower anticoagulation levels after mechanical heart valve replacement.国际标准化比值（INR）自我管理可使机械心脏瓣膜置换术后的抗凝水平降低。
Circulation. 2003 Sep 9;108 Suppl 1:II75-8. doi: 10.1161/01.cir.0000089185.80318.3f.
10
AREVA: multicenter randomized comparison of low-dose versus standard-dose anticoagulation in patients with mechanical prosthetic heart valves.阿海珐公司：机械人工心脏瓣膜患者低剂量与标准剂量抗凝治疗的多中心随机对照研究
Circulation. 1996 Nov 1;94(9):2107-12. doi: 10.1161/01.cir.94.9.2107.

引用本文的文献

1
Biological Surgical Options in Young Patients for the Treatment of Severe Aortic Stenosis: Is the Jury Still Out? A Review.年轻患者严重主动脉瓣狭窄治疗中的生物外科手术选择：尚无定论？综述
Rev Cardiovasc Med. 2022 Jul 26;23(8):274. doi: 10.31083/j.rcm2308274. eCollection 2022 Aug.

本文引用的文献

1
Patients' attitude and knowledge about oral anticoagulation therapy: results of a self-assessment survey in patients with atrial fibrillation conducted by the European Heart Rhythm Association.患者对抗凝治疗的态度和认知：欧洲心律协会针对房颤患者开展的一项自我评估调查结果
Europace. 2016 Jan;18(1):151-5. doi: 10.1093/europace/euv317. Epub 2015 Oct 12.
2
Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation.达比加群在减轻机械心脏瓣膜诱导的凝血酶生成方面不如华法林有效。
J Am Heart Assoc. 2015 Aug 24;4(8):e002322. doi: 10.1161/JAHA.115.002322.
3
The perimount valve in the aortic position: twenty-year experience with patients under 60 years old.
主动脉瓣位的瓣周漏：60 岁以下患者 20 年的经验。
Ann Thorac Surg. 2014 May;97(5):1526-32. doi: 10.1016/j.athoracsur.2014.02.019. Epub 2014 Mar 28.
4
Reduced anticoagulation after mechanical aortic valve replacement: interim results from the prospective randomized on-X valve anticoagulation clinical trial randomized Food and Drug Administration investigational device exemption trial.机械主动脉瓣置换术后的抗凝治疗降低：前瞻性随机 ON-X 瓣膜抗凝临床试验随机食品和药物管理局研究性器械豁免试验的中期结果。
J Thorac Cardiovasc Surg. 2014 Apr;147(4):1202-1210; discussion 1210-1. doi: 10.1016/j.jtcvs.2014.01.004. Epub 2014 Jan 12.
5
Long-term outcomes after elective isolated mechanical aortic valve replacement in young adults.年轻成人择期孤立性机械主动脉瓣置换术后的长期结局
J Thorac Cardiovasc Surg. 2014 Oct;148(4):1341-1346.e1. doi: 10.1016/j.jtcvs.2013.10.064. Epub 2013 Dec 9.
6
What is the role of the Ross procedure in today's armamentarium?罗斯手术在当今的治疗手段中扮演什么角色？
Can J Cardiol. 2013 Dec;29(12):1569-76. doi: 10.1016/j.cjca.2013.08.009.
7
The Ross procedure: outcomes at 20 years.罗斯手术：20 年随访结果。
J Thorac Cardiovasc Surg. 2014 Jan;147(1):85-93. doi: 10.1016/j.jtcvs.2013.08.007. Epub 2013 Sep 29.
8
Dabigatran versus warfarin in patients with mechanical heart valves.达比加群酯与华法林用于机械心脏瓣膜患者的比较。
N Engl J Med. 2013 Sep 26;369(13):1206-14. doi: 10.1056/NEJMoa1300615. Epub 2013 Aug 31.
9
Carpentier-Edwards pericardial valve in the aortic position: 25-years experience.Carpentier-Edwards 心脏生物瓣在主动脉瓣位：25 年的经验。
Ann Thorac Surg. 2013 Aug;96(2):486-93. doi: 10.1016/j.athoracsur.2013.03.032. Epub 2013 May 14.
10
Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-in-valve registry.经导管主动脉瓣置换术治疗退行性生物瓣外科瓣膜：全球瓣中瓣注册研究结果。
Circulation. 2012 Nov 6;126(19):2335-44. doi: 10.1161/CIRCULATIONAHA.112.104505. Epub 2012 Oct 10.