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年轻患者严重主动脉瓣狭窄治疗中的生物外科手术选择:尚无定论?综述

Biological Surgical Options in Young Patients for the Treatment of Severe Aortic Stenosis: Is the Jury Still Out? A Review.

作者信息

Khalil Khalil, Forcillo Jessica

机构信息

Department of Cardiac Surgery, Centre Hospitalier de l'université de Montréal (CHUM), Montreal, QC H2X 0C1, Canada.

Department of Surgery, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.

出版信息

Rev Cardiovasc Med. 2022 Jul 26;23(8):274. doi: 10.31083/j.rcm2308274. eCollection 2022 Aug.

Abstract

Aortic interventions remain the most effective treatment for severe aortic stenosis. In the recent years, advances in bioprosthetics and newer data have reduced the cut-off age for the use of bioprosthetic valves in younger patients, but the debate on whether to favor mechanical valves in younger patients remains a constant, especially with the undesired effects and considerations of anticoagulation therapy with vitamin K antagonists in this age group. Other options like the Ross procedure are gaining traction, despite still being undervalued and necessitating expertise centers. Hemodynamic considerations and durability of these options are important to consider, especially in this age group. Regardless of the choice of the prosthesis, patient informed consent is paramount since the decision affects the lifetime management of their initial condition, and expectations given must remain realistic.

摘要

主动脉干预仍然是重度主动脉瓣狭窄最有效的治疗方法。近年来,生物假体的进展和新的数据降低了年轻患者使用生物人工瓣膜的年龄界限,但对于年轻患者是否更适合使用机械瓣膜的争论一直存在,尤其是考虑到该年龄组使用维生素K拮抗剂进行抗凝治疗的不良影响。尽管罗斯手术等其他选择仍未得到充分重视且需要专业中心来开展,但它们正越来越受到关注。对于这些选择,血流动力学因素和耐用性很重要,尤其是在这个年龄组。无论选择何种假体,患者的知情同意至关重要,因为这一决定会影响其初始病情的终生管理,而且所给出的预期必须保持现实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4c/11266961/72a2b57907d9/2153-8174-23-8-274-g1.jpg

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